- Tytuł:
- Cyklooksygenaza-2 i jej rola w kancerogenezie
- Autorzy:
-
Sitarz, Robert
Kolasińska-Bzoma, Małgorzata
Skórzewska, Magdalena
Polkowski, Wojciech P.
Maciejewski, Ryszard - Powiązania:
- https://bibliotekanauki.pl/articles/1034192.pdf
- Data publikacji:
- 2012
- Wydawca:
- Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
- Tematy:
-
cyklooksygenaza
enzym cyklooksygenazy
neoangiogeneza
rak
reakcje katalizowane przez COX-2 oraz COX-1
syntazą prostaglandyny H
terapia chorób nowotworowych - Opis:
- Cyclooxygenase is an enzyme involved in many physiological and pathological processes. It catalyzes the formation of prostaglandins, prostacyclins and thromboxanes from arachidonic acid. It has been reported that cyclooxygenase-2 (COX-2) modulates the secretion of proinflammatory mediators and its expression is associated with the promotion of the process of tumorigenesis initiation, transformation, progression and cancer metastasis. Increased expression of COX-2 in premalignant lesions makes it a key element in a chain of changes leading to cancer. So far, advances in the evaluation of COX -2 molecular mechanisms did not bring spectacular discoveries. Pathomechanisms of COX-2 activities are still not sufficiently understood and therefore, require further research. Currently, COX-2 inhibitors are one of the most commonly used medications. Unfortunately, their long-term use causes many side effects. The first report about the use of plant substances with anti-inflammatory and analgesic activity (COX-2 inhibitors) was reported by Hippocrates in the 5th century BC. The present review discusses the most important mechanisms by which a particular COX-2 isomer leads to the formation and development of cancer.
- Źródło:
-
Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe; 2012, 5; 19-39
2082-3827
2084-977X - Pojawia się w:
- Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe
- Dostawca treści:
- Biblioteka Nauki
Artykuł