- Tytuł:
- Effect of collagen fibres and elastic lamellae content on the mechanical behaviour of abdominal aortic aneurysms
- Autorzy:
- Kobielarz, Magdalena
- Powiązania:
- https://bibliotekanauki.pl/articles/27324131.pdf
- Data publikacji:
- 2020
- Wydawca:
- Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
- Tematy:
-
abdominal aortic aneurysm
mechanical properties
constitutive modelling
uniaxial tensile loading
collagen fibres
elastic lamellae
tętniak aorty brzusznej
właściwości mechaniczne
modelowanie konstytutywne
jednoosiowe obciążenie rozciągające
włókna kolagenowe
elastyczne lamele - Opis:
- Purpose: The main purpose of this study was a detailed analysis of the mechanical and structural characteristics of human abdominal aneurysms in comparison with normal abdominal aortae and determination of the correlations between their mechanical behaviour and the microstructural content. Methods: Various mechanical properties, i.e., mechanical failure properties, elastic moduli, inflection point coordinates, index of anisotropy and incompressibility were determined under uniaxial loading conditions in the circumferential and axial directions. Constitutive parameters were derived from the commonly used constitutive model proposed by Holzapfel et al. [9]. The microstructural arrangement was examined by histological staining supported by scanning electron microscopy analysis. The content of collagen fibres and elastic lamellae was tested in relation to mechanical properties and constitutive parameters. Results: Significant differences were found in the microstructural arrangement and layer composition of the aneurysmal specimens, compared to the normal aorta group. The mechanical properties and constitutive parameters of the aneurysmal specimens were significantly altered, indicating a weakening of the load-bearing properties of the walls of the aneurysms. A comparative analysis discovered significant correlations between structural composition and mechanical parameters, in particular with respect to the number of collagen fibres and failure stress, which can be important for clinical evaluation of abdominal aortic aneurysm (AAA) rupture. Conclusions: Changes in the content of collagen fibres and elastic lamellae correlate with mechanical and constitutive parameters, indicating AAA severity
- Źródło:
-
Acta of Bioengineering and Biomechanics; 2020, 22, 3; 9--21
1509-409X
2450-6303 - Pojawia się w:
- Acta of Bioengineering and Biomechanics
- Dostawca treści:
- Biblioteka Nauki
Artykuł