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Tytuł:
Alcohol-related Developmental Origin of Adult Health – population studies in Poland among mothers and newborns (2010-2012)
Autorzy:
Wojtyla, A.
Kapka-Skrzypczak, L.
Diatczyk, J.
Fronczak, A.
Paprzycki, P.
Powiązania:
https://bibliotekanauki.pl/articles/50850.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Alcohol related harm is a global problem for public health where frequent consumption of large amounts of alcohol constitutes a serious health risk, particularly to vulnerable groups such as adolescents, pregnant women and newborns. The epidemiological study on health-lifestyle behaviour, especially alcohol consumption, was performed on a randomised group of post-partum women’s health behaviour during pregnancy, covering drinking habits, was undertaken in 2010, 2011 and 2012, (n=8,237) according to the PRAMS model including effects on the foetus and newborn; women being selected from obstetric and gynaecological wards. In this Polish study, only 14% of women did not consume alcohol before becoming pregnant while 15% of women drank alcohol throughout the entire period of pregnancy. In addition, awareness of the harmful effects of alcohol consumed, especially of small amounts, before and during pregnancy is low among Polish women. It is also alarming that more than 55% of physicians who provide care for pregnant women do not discuss with them the harmful effect of alcohol on the organism of the mother and foetus, whereas over 2% of doctors even recommend the consumption of alcohol in pregnancy. With reference to the Barker’s Foetal Origin of Diseases Hypothesis, the authors suggest such alcohol drinking behaviour of women during their reproductive ages and while pregnant may exert negative health effects on offspring, mainly in the form of susceptibility to contracting chronic diseases. Such findings pose a risk to future generations in Poland and require remedial/educational action targeted on health care professionals and public like.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Designer Drug (DD) abuse in Poland; a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof. Part 1 – Cannabinoids and Cathinones
Autorzy:
Bilinski, P.
Holownia, P.
Kapka-Skrzypczak, L.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/50408.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular and environmental aspects of skin cancers
Autorzy:
Zebracka, A.
Matysiak, M.
Dudra-Jastrzebska, M.
Kapka-Skrzypczak, L.
Powiązania:
https://bibliotekanauki.pl/articles/3509.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
molecular aspect
environmental aspect
skin
cancer
malignant melanoma
basal cell carcinoma
squamous cell carcinoma
ultraviolet radiation
carcinogenesis
Opis:
Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Designer Drug (DD) abuse in Poland; a review of the psychoactive and toxic properties of substances found from seizures of illegal drug products and the legal consequences thereof. Part II – Piperazines/Piperidines, Phenylethylamines, Tryptamines and miscellaneous ‘Others’
Autorzy:
Bilinski, P.
Holownia, P.
Kapka-Skrzypczak, L.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/49528.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical activity among women at reproductive age and during pregnancy (Youth Behavioural Polish Survey - YBPS and Pregnancy-related Assessment Monitoring Survay - PrAMS) - epidemiological population studies in Poland during the period 2010-2011
Autorzy:
Wojtyla, A.
Kapka-Skrzypczak, L.
Bilinski, P.
Paprzycki, P.
Powiązania:
https://bibliotekanauki.pl/articles/50037.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Tematy:
physical activity
woman
reproductive age
pregnancy
risk
public health
epidemiological study
Polish population
Polska
2010-2011 period
Źródło:
Annals of Agricultural and Environmental Medicine; 2011, 18, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical activity among women at reproductive age and during pregnancy (Youth Behavioural Polish Survey – YBPS and Pregnancy-related Assessment Monitoring Survay – PrAMS) – epidemiological population studies in Poland during the period 2010-2011
Autorzy:
Wojtyla, A.
Kapka-Skrzypczak, L.
Bilinski, P.
Paprzycki, P.
Powiązania:
https://bibliotekanauki.pl/articles/51114.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Tematy:
physical activity
woman
reproductive age
pregnancy
human behaviour
pregnancy risk
monitoring
epidemiological study
Polish population
Polska
2010-2011 period
Źródło:
Annals of Agricultural and Environmental Medicine; 2011, 18, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kwas foliowy - skutki niedoboru i zasadność suplementacji
Folic acid - effects of deficiency and justification for supplementation
Autorzy:
Kapka-Skrzypczak, L.
Niedzwiecka, J.
Skrzypczak, M.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/4443.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Źródło:
Medycyna Ogólna i Nauki o Zdrowiu; 2012, 18(47), 1
2083-4543
Pojawia się w:
Medycyna Ogólna i Nauki o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiological studies in Poland on effect of physical activity of pregnant women on the health of offspring and future generations – adaptation of the hypothesis Development Origin of Health and Diseases
Autorzy:
Wojtyla, A.
Kapka-Skrzypczak, L.
Paprzycki, P.
Skrzypczak, M.
Bilinski, P.
Powiązania:
https://bibliotekanauki.pl/articles/49302.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
It is recognized that the levels of women’s physical activity during pregnancy has a direct bearing on the method of delivery and health of the newborn. The main objective of the study was investigation the level of physical activity of women during pregnancy according to the Pregnancy Physical Activity Questionnaire (PPAQ). The subjects of this study were n=2852 post-partum women surveyed together with their newborns, representing all obstetric hospital departments throughout Poland. The questionnaires were completed on a single day during the second week of November 2011. The women were also asked about the amount, range and type of physical activity they performed before becoming pregnant. The Pregnancy Physical Activity Questionnaire was used for precisely measuring physical activity according to the standard metabolically equivalent (MET). In addition, comparisons were made between the weight of the infant and newborn status using the APGAR scale with the amount of physical activity performed by the mothers. There were decidedly low physical activity levels observed in pregnant women compared to those before becoming pregnant. Appropriate interventions can therefore now be targeted through remedial action in Poland. It is important to perform intervention studies intended to test this hypothesis and attempt to identify the most appropriate levels for intensity, duration and frequency of physical exercise during pregnancy. The studies should consider the four domains of daily physical activity and utilize tools that reliably measure exposure variables. Such studies would provide valuable information for recommendations about physical activity during pregnancy.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physical activity of Polish adolescents and young adults according to IPAQ: a population based study
Autorzy:
Bergier, J.
Kapka-Skrzypczak, L.
Bilinski, P.
Paprzycki, P.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/50624.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
The alarming problem of a decline in physical activity among children and adolescents and its detrimental effects on public health has been well recognised worldwide. Low physical activity is responsible for 6% of deaths worldwide and 5-10% of deaths in the countries of the WHO European Region, according to country. Within the last decade, many initiatives have been launched to counteract this phenomenon. The objective of presented study was analysis of the level of physical activity among adolescents and young adults in Poland, according to the IPAQ questionnaire. The study group covered 7,716 adolescents: 5,086 children attending high school and secondary schools and 2,630 university students. Low physical activity was noted among 57% of schoolchildren and 20.84% of students. Analysis of the level of physical activity according to the IPAQ indicated that it was lower among girls, compared to boys. An additional analysis, with the consideration of the place of residence, showed that the highest percentage of the population with low physical activity was noted in the rural areas (29.30%), while among the urban inhabitants of cities with a population above 100,000 it was on the level of 23.69% and 20.57%. Median for weekly physical activity by respondents` gender was on the level of 1,554.00 MET*min. weekly among females, and 2,611.00 MET*min. weekly among males (p<0.000). The highest weekly physical activity expressed in MET*min. was observed among the inhabitants of towns with a population less than 100,000, whereas among the rural population and inhabitants of large cities with a population of over 100,000 the weekly physical activity was on a similar level (1,830.50 and 1,962.00 respectively). An extended analysis of respondents’ physical activity showed that during the day students spend significantly more time in a sedentary position, compared to schoolchildren. The presented results of studies indicate the necessity to continue and intensify actions to promote various forms of physical activity among students and schoolchildren. A constant decrease in physical activity observed among children and adolescents suggests that it is necessary to pay greater attention to this social group while developing health programmes.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dieta ciężarnej a ryzyko wad wrodzonych dziecka
Diet in pregnancy and risk of birth defects
Autorzy:
Kapka-Skrzypczak, L.
Niedzwiecka, J.
Skrzypczak, M.
Diatczyk, J.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/3876.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Źródło:
Medycyna Ogólna i Nauki o Zdrowiu; 2011, 17(46), 4
2083-4543
Pojawia się w:
Medycyna Ogólna i Nauki o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dopalacze - stan aktualny i wytyczne na przyszłość
Legal highs - current state and guidelines for the future
Autorzy:
Kapka-Skrzypczak, L.
Cyranka, M.
Kulpa, P.
Skrzypczak, M.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/4568.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Źródło:
Medycyna Ogólna i Nauki o Zdrowiu; 2011, 17(46), 4
2083-4543
Pojawia się w:
Medycyna Ogólna i Nauki o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plasma and erythrocyte relationship of catecholamines in haemodialysis patients
Autorzy:
Dziedzic, M.
Bednarek-Skublewska, A.
Solski, J.
Kapka-Skrzypczak, L.
Powiązania:
https://bibliotekanauki.pl/articles/50173.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2014, 21, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cholinesterase activity in blood and pesticide presence in sweat as biomarkers of childrens environmental exposure to crop protection chemicals
Autorzy:
Kapka-Skrzypczak, L.
Sawicki, K.
Czajka, M.
Turski, W.A.
Powiązania:
https://bibliotekanauki.pl/articles/50693.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2015, 22, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Środki ochrony roślin a zdrowie rolników – biomarkery oraz możliwości ich wykorzystania do oceny ekspozycji na pestycydy
Plant protection products and farmers’ health – perspectives of the application of biomarkers for evaluation of exposure to pesticides and its biological eff ects
Autorzy:
Kapka-Skrzypczak, L.
Cyranka, M.
Kruszewski, M.
Turski, W.A.
Powiązania:
https://bibliotekanauki.pl/articles/941328.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Tematy:
pestycydy fosfoorganiczne
biomarkery narażenia
biomarkery skutków
genotoksyczność
Opis:
Pestycydy to substancje syntetyczne lub naturalne stosowane do zwalczania organizmów szkodliwych lub niepożądanych. Wśród obecnie stosowanych insektycydów najbardziej niebezpieczne, ze względu na ryzyko ostrych zatruć, są związki fosforoorganiczne. Jednak także długotrwała ekspozycja na toksyczne działanie pestycydów w najbliższym otoczeniu lub środowisku pracy niesie ze sobą ryzyko zdrowotne. Stopień narażenia środowiskowego i zawodowego na działanie insektycydów fosfoorganicznych może być monitorowany za pomocą biologicznych wskaźników oceniających ekspozycję, ryzyko zdrowotne czy osobniczą wrażliwość na toksyczne działanie tych pestycydów. Praca przedstawia najczęściej stosowane biomarkery wczesnych skutków biologicznych ekspozycji na pestycydy fosfoorganiczne, ze szczególnym naciskiem na genotoksyczne skutki powodowane narażeniem na te związki. Podsumowuje również możliwości i ograniczenia, jakie posiadają biomarkery wykorzystywane do oceny i identyfi kacji ekspozycji środowiskowej/zawodowej na działanie pestycydów.
Źródło:
Medycyna Ogólna i Nauki o Zdrowiu; 2011, 17(46), 1; 29-32
2083-4543
Pojawia się w:
Medycyna Ogólna i Nauki o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epigenetic regulation in drug addiction
Autorzy:
Bilinski, P.
Wojtyla, A.
Kapka-Skrzypczak, L.
Chwedorowicz, R.
Cyranka, M.
Studzinski, T.
Powiązania:
https://bibliotekanauki.pl/articles/50469.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
The interaction between environmental signals and genes has now taken on a clear molecular form as demonstrated by stable changes in chromatin structure. These changes occur through activation or repression of specific gene programmes by a combination of chromatin remodelling, activation and enzymatic modification of DNA and histones as well as nucleosomal subunit exchange. Recent research investigating the molecular mechanisms controlling drug-induced transcriptional, behavioural and synaptic activity has shown a direct role for chromatin remodelling – termed as epigenetic regulation – of neuronal gene programmes and subsequent addictive behaviour arising from it. Recent data suggest that repeated exposure to certain drugs promotes changes in levels of histone acetylation, phosphorylation and methylation, together with alterations in DNA methylation levels in the neurons of the brain reward centre, localised in the Nucleus Accumbens (NAc) region of the limbic system. The combination of acetylating, phosphorylating and methylating H3 and H4 histone tails alter chromatin compaction thereby promoting altered levels of cellular gene expression. Histone modifications, which weaken histone interaction with DNA or that promote recruitment of transcriptional activating complexes, correlate with permissive gene expression. Histone deacetylation, (which strengthen histone: DNA contacts), or histone methylation, (which recruits repressive complexes to chromatin), promote a state of transcriptional repression. Using animal models, acute cocaine treatment increases H4 acetylation at acutely regulated gene promoters, whereas H3 acetylation appears to predominate at chronically induced promoters. Chronic cocaine and alcohol treatment activate and repress many genes such as FosB, Cdk5, and Bdnf, where their dysregulation, at the chromatin level, contribute to the development and maintenance of addiction. Following drug exposure, it is still unknown, howver, how long these changes in chromatin structure persist in affecting neuronal function, but some do so for life.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł

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