- Tytuł:
-
Preliminary evaluation of maternotoxic effect of Ascaris alpha-chymotrypsin inhibitor in mice
WSTĘPNA OCENA TOKSYCZNEGO DZIAŁANIA INHIBITORA о-СНУМОТВУРЗУМУ 7 ASCARIS NA ORGANIZM CIĘŻARNYCH MYSZY - Autorzy:
-
Blaszkowska, J.
Kadłubowski, R. - Powiązania:
- https://bibliotekanauki.pl/articles/2148308.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Parazytologiczne
- Tematy:
-
parasite
pregnancy
mouse
mice
Ascaris
host organism
toxic effect
alpha-chymotrypsin inhibitor - Opis:
- Administration intraperitoneally of the Ascaris α-chymotrypsin inhibitor (40-300 mg/kg/day.) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. The low doses of α-chymotrypsin inhibitor (40-80 mg/kg/day) significantly decreased the number of live fetuses per litter, increased the number of fetal resorptions. The symptoms of matemal toxicity that occurred after administration of the highest doses of the inhibitor (80-300 mg/kg/day) to pregnant mice included: decreased body weight gain as compared to control, vaginal hemorrhage, intrauterine resorption of litters, abortions, altered behaviour of animals immediately after injection and death. There is a linear interrelationship between the logarithm of the doses of the inhibitor and mortality of pregnant mice. The DL50 value of the inhibitor for female was 116 mg/kg /day (confidence interval: 95.5-140.0 mg/kg/day).
- Źródło:
-
Wiadomości Parazytologiczne; 2001, 47, 4; 705-710
0043-5163 - Pojawia się w:
- Wiadomości Parazytologiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł