- Tytuł:
- Ovocystatin affects actin cytoskeleton organization and induces proapoptotic activity
- Autorzy:
-
Malicka-Blaszkiewicz, Maria
Filipczak, Nina
Gołąb, Krzysztof
Juszczyńska, Katarzyna
Sebzda, Tadeusz
Gburek, Jakub - Powiązania:
- https://bibliotekanauki.pl/articles/1039207.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
ovocystatin
egg white cystatin
actin cytoskeleton
apoptosis - Opis:
- Ovocystatin is a chicken egg white protein, generally known for its inhibitory activity against cysteine proteases. However, biological activity of ovocystatin does not seem to be well recognized in respect to other possible cellular effects. Our attention has been focused on ovocystatin cytotoxic effects in relation to its influence on actin cytoskeleton organization and apoptosis induction. In vitro studies with human melanoma A375, human cervix HeLa cancer cells and normal human fibroblasts - NHDF were done. Cytotoxic activity of ovocystatin was seen in respect to apoptosis induction - manifested by cell shape changes, phosphatydylserine translocation and actin cytoskeleton reorganization. Normal human fibroblasts have shown lower sensitivity to ovocystatin as compared with human melanoma A375 and human cervix HeLa cancer cells. In conclusion, ovocystatin affects actin cytoskeleton organization and displays proapoptotic activity towards applied cell lines. This implicates its application as a potential anticancer drug. However, its adverse effects on normal cells should be taken into consideration.
- Źródło:
-
Acta Biochimica Polonica; 2014, 61, 4; 753-758
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł