- Tytuł:
- Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy
- Autorzy:
-
Roś-Mazurczyk, Małgorzata
Wojakowska, Anna
Marczak, Łukasz
Polański, Krzysztof
Pietrowska, Monika
Jelonek, Karol
Domińczyk, Iwona
Hajduk, Agata
Rutkowski, Tomasz
Składowski, Krzysztof
Widłak, Piotr - Powiązania:
- https://bibliotekanauki.pl/articles/1038706.pdf
- Data publikacji:
- 2017
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
head and neck cancer
mass spectrometry
metabolomics
radiation response
serum metabolome - Opis:
- Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.
- Źródło:
-
Acta Biochimica Polonica; 2017, 64, 1; 189-193
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł