- Tytuł:
- Antitumour activity of Salmonella typhimurium VNP20047 in B16(F10) murine melanoma model.
- Autorzy:
-
Jazowiecka-Rakus, Joanna
Szala, Stanisław - Powiązania:
- https://bibliotekanauki.pl/articles/1041570.pdf
- Data publikacji:
- 2004
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
cancer gene therapy
tumour targeting
cytosine deaminase
Salmonella - Opis:
- A tumour therapy is proposed based on attenuated Salmonella typhimurium VNP20047 expressing the Escherichia coli cytosine deaminase gene. VNP20047 was administered intravenously to B16(F10) melanoma-bearing C57BL/6 mice. VNP20047 proliferated within tumours and livers regardless of the initial inoculum dose. After 10 days the number of bacteria increased in livers up to 4.2 × 106 cfu/g and decreased in tumours down to 5.9 × 106 cfu/g. VNP20047 at 1 × 105 cfu/mouse, when combined with 5-fluorocytosine, inhibited tumour growth by 85% without prolonging animal survival. Histology studies revealed severe lesions in tumours and livers. These data suggest that S. typhimurium VNP20047 induced inflammatory responses, even though the strain was attenuated.
- Źródło:
-
Acta Biochimica Polonica; 2004, 51, 3; 851-856
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł