- Tytuł:
- Prostaglandin E2 inhibits IL-10 production by bovine CD4plus T cells
- Autorzy:
-
Zuska-Prot, M.
Maslanka, T.
Jasiecka, A.
Jaroszewski, J.J. - Powiązania:
- https://bibliotekanauki.pl/articles/31834.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polska Akademia Nauk. Czytelnia Czasopism PAN
- Opis:
- Although prostaglandin E₂ (PGE₂) is a pro-inflammatory mediator, it also produces some effect which is anti-inflammatory in character. It is suggested that one of the mechanisms responsible for the latter effect is the increased synthesis of IL-10. The aim of this study has been to determine the influence of PGE₂ on IL-10 production by bovine CD⁴⁺ and CD⁸⁺ T cells and NK cells. With this aim, peripheral blood mononuclear cells collected from 12-month-old heifers (n = 10) were treated without or with PGE₂ (10⁻⁶ M). Flow cytometric analysis showed that PGE₂ caused a reduction in the percentage of IL-10 producing CD⁴⁺ T cells (P < 0.001), while leaving the secretion of this cytokine by CD⁸⁺ T cells and NK cells unaffected. This seems to indicate that PGE₂ in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10; contrary to this, it may aggravate an inflammatory response by inhibiting the secretion of this cytokine by CD⁴⁺ T cells.
- Źródło:
-
Polish Journal of Veterinary Sciences; 2014, 17, 3
1505-1773 - Pojawia się w:
- Polish Journal of Veterinary Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł