- Tytuł:
- Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents
- Autorzy:
-
Igbe, Ighodaro
Edosuyi, Osaze
Okhuarobo, Agbonlahor
Pongri, Adarki
Maduako, Nkechi
Ehimen, Isaac - Powiązania:
- https://bibliotekanauki.pl/articles/2048743.pdf
- Data publikacji:
- 2019
- Wydawca:
- Instytut Włókien Naturalnych i Roślin Zielarskich
- Tematy:
-
Cussonia barteri
methanol leaf extract
anti-inflammatory activity
analgesic activity
metanolowy wyciąg z liści
działanie przeciwzapalne
działanie przeciwbólowe - Opis:
- Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests. Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.
- Źródło:
-
Herba Polonica; 2019, 65, 3; 22-31
0018-0599 - Pojawia się w:
- Herba Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł