- Tytuł:
- Preparation and cytological study of collagen/nano-hydroxyapatite/graphene oxide composites
- Autorzy:
-
Wang, J.
Wang, Y.
Liu, D.
Yang, Q.
Huang, C.
Yang, C.
Zhang, Q. - Powiązania:
- https://bibliotekanauki.pl/articles/307450.pdf
- Data publikacji:
- 2018
- Wydawca:
- Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
- Tematy:
-
nanohydroksyapatyt
tlenek grafitu
mineralizacja
kolagen
nano-hydroxyapatite
graphene oxide
biomimetic mineralization
collagen - Opis:
- Biomimetic mineralized composite scaffolds are widely used as natural bone substitute materials in tissue engineering by inducing and assembling bonelike apatite. In this study, the single lamellar structure of graphene oxide (GO) powder was prepared via an improved Hummers’ method. Methods: To better mimic natural bone, the collagen (COL)/Nano-hydroxyapatite (nHA)/graphene oxide (GO) composite material was prepared by simulated body fluid (SBF) method using COL/GO as a matrix template. Hydroxyapatite (HA) with calcium ion deficiency was achieved via biomimetic mineralization, and it had properties closer to those of natural bone than pure HA has. Results: The mineralized COL/nHA/GO composites exhibited loose porous structures, and the connectivity of the holes was good and thus beneficial to the exchange of nutrients and excreted metabolites. Conculsions: Antibacterial and MTT experiment confirmed that the COL/nHA/GO composite material had excellent antibacterial property and biocompatibility. Hence, these results strongly suggested the mineralized COL/nHA/GO composite is a good candidate biomaterial to be applied in bone tissue engineering.
- Źródło:
-
Acta of Bioengineering and Biomechanics; 2018, 20, 4; 65-74
1509-409X
2450-6303 - Pojawia się w:
- Acta of Bioengineering and Biomechanics
- Dostawca treści:
- Biblioteka Nauki
Artykuł