- Tytuł:
- Optimizing the conditions of PGSu synthesiswith simplex method
- Autorzy:
-
Wrzecionek, Michał
Howis, Joanna
Ruśkowski, Paweł
Gadomska-Gajadhur, Agnieszka - Powiązania:
- https://bibliotekanauki.pl/articles/185166.pdf
- Data publikacji:
- 2020
- Wydawca:
- Polska Akademia Nauk. Czytelnia Czasopism PAN
- Tematy:
-
poly(glycerol succinate)
polycondensation
glycerol polyesters
biomaterials
optimization
poli (bursztynian glicerolu)
polikondensacja
poliestry glicerolu
biomateriały
optymalizacja - Opis:
- Poly(glycerol succinate) – PGSu – is one of glycerol polyesters which has focused nowadays the interestof scientists developing new biomaterials. Probably the polyester could be used as a drug carrier or asa cell scaffold in tissue engineering. Due to its potential use in medicine, it is extremely important todevelop a synthesis and then optimize it to obtain a material with desired properties. In this work oneflask two-step polycondensation of glycerol and succinic anhydride to PGSu is presented. Synthesiswas optimized with the simplex method and also described using a second-degree equation with twovariables (temperature and time) to better find the optimum conditions. PGSu was characterized byFTIR spectroscopy, NMR spectroscopy, degree of esterification was determined, and also molecularweight was calculated for each experiment using Carothers equation. A new synthesis route wasdeveloped and optimized. Temperature and time influence on molecular weight and esterificationdegree of obtained polyester are presented. Based on experiments conducted in this work, it waspossible to obtain poly(glycerol succinate) with molecular weight of 6.7 kDa.
- Źródło:
-
Chemical and Process Engineering; 2020, 41, 2; 119--128
0208-6425
2300-1925 - Pojawia się w:
- Chemical and Process Engineering
- Dostawca treści:
- Biblioteka Nauki
Artykuł