- Tytuł:
- Inhibition of the helicase activity of HCV NTPase/helicase by 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5-triphosphate (ribavirin-TP).
- Autorzy:
-
Borowski, Peter
Lang, Melanie
Niebuhr, Andreas
Haag, Annemarie
Schmitz, Herbert
Schulze zur Wiesch, Julian
Choe, Joonho
Siwecka, Maria
Kulikowski, Tadeusz - Powiązania:
- https://bibliotekanauki.pl/articles/1044103.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
ribavirin-5'-triphosphate
enzyme inhibition
HCV helicase - Opis:
- In the presented study the ribavirin-TP - an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II - was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase. The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity. Our results suggest that derivatives of ribavirin-TP with enhanced stability towards hydrolytic attack may be effective inhibitors of the enzyme.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 3; 739-744
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł