- Tytuł:
- Isolation and expression pattern of RGS21 gene, a novel RGS member
- Autorzy:
-
Li, Xin
Chen, Lei
Ji, Chaoneng
Liu, Bing
Gu, Jiefeng
Xu, Jian
Zou, Xianqiong
Gu, Shaohua
Mao, Yumin - Powiązania:
- https://bibliotekanauki.pl/articles/1041351.pdf
- Data publikacji:
- 2005
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
RGS21
G-protein signaling pathway
G-protein α subunit (Gα) - Opis:
- Regulators of G-protein signaling (RGS) proteins are known for the RGS domain that is composed of a conserved stretch of 120 amino acids, which binds directly to activated G-protein α subunits and acts as a GTPase-activating protein (GAP), leading to their deactivation and termination of downstream signals. In this study, a novel human RGS cDNA (RGS21), 1795 bp long and encoding a 152-amino acid polypeptide, was isolated by large-scale sequencing analysis of a human fetal brain cDNA library. Unlike other RGS family members, RGS21 gene has no additional domain/motif and may represent the smallest known member of RGS family. It may belong to the B/R4 subfamily, which suggests that it may serve exclusively as a negative regulator of αi/o family members and/or αq/11. PCR analysis showed that RGS21 mRNA was expressed ubiquitously in the 16 tissues examined, implying general physiological roles.
- Źródło:
-
Acta Biochimica Polonica; 2005, 52, 4; 943-946
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł