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Wyświetlanie 1-3 z 3
Tytuł:
Green tea and comprehensive healing properties of polyphenols
Autorzy:
Grzywacz, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1033834.pdf
Data publikacji:
2012
Wydawca:
Zakład Opieki Zdrowotnej Ośrodek Umea Shinoda-Kuracejo
Tematy:
antioxidants
polyphenols
tea
Opis:
Tea, Camellia sinensis L. is the most widely drunk beverage in the world. Comprehensive healing properties of this refreshing, mildly stimulating drink are known in traditional medicine dating back almost 5000 years. Tea healing and disease prevention mechanism is mostly based on antioxidant properties. Tea beverage is a rich source of polyphenols, especially catechins which are very powerful antioxidants. The most abundant catechins in tea beverage are epigallocatechin 3-gallate (EGCG), epigallocatechin (EGC), epicatechin 3-gallate (ECG), and epicatechin (EC). Many investigations i.e. population-based, screening, involving patients and also with animal or cell models, show many valuable pharmacological properties of tea. It is proved by numerous studies that drinking tea or taking tea extracts can prevent chronic diseases, including coronary heart disease and many types of cancer. It can also help with diabetes, hypertension and obesity and may contribute to inflammation reduce. Better understanding of tea healing properties could help reduce high costs of medical care, improve treatment of lifestyle diseases, and transform tea beverage into an evidence based functional food.
Źródło:
Medicina Internacia Revuo; 2012, 25, 98; 3-13
0465-5435
Pojawia się w:
Medicina Internacia Revuo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
Autorzy:
Grzywacz, Agata
Gdula-Argasińska, Joanna
Muszyńska, Bożena
Tyszka-Czochara, Małgorzata
Librowski, Tadeusz
Opoka, Włodzimierz
Powiązania:
https://bibliotekanauki.pl/articles/1038990.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metal responsive-transcription factor 1
cell signaling
inflammation
NF-κB
Opis:
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 491-498
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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