- Tytuł:
- The level of endogenous DNA damage in lymphocytes isolated from blood is associated with the fluctuation of 17β-estradiol concentration in the follicular phase of healthy young women.
- Autorzy:
-
Kapiszewska, Maria
Kalemba, Malgorzata
Grzesiak, Aneta
Kocemba, Kinga - Powiązania:
- https://bibliotekanauki.pl/articles/1041444.pdf
- Data publikacji:
- 2005
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
endogenous DNA damage
catechol-O-methyltransferase (COMT)
comet assay
17β-estradiol - Opis:
- The aim of this study was to evaluate whether the differences in plasma 17β-estradiol concentration in early and late follicular phases of the menstrual cycle can affect the level of endogenous DNA damage in lymphocytes assessed by comet assay, and whether the extent of this damage in the follicular phase is associated with the genotype of catechol-O-methyltransferase (COMT). The level of DNA damage was positively correlated with 17β-estradiol concentration only in the late follicular phase. Subjects with the COMT L/L homozygous mutated variant revealed more DNA damage as compared to individuals with the COMT wild-type and heterozygous (H/L+HH) genotype.
- Źródło:
-
Acta Biochimica Polonica; 2005, 52, 2; 535-539
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł