- Tytuł:
- Clinical usefulness of MMP-2 and TIMP-2 concentrations in the preoperative serum of patients with colorectal cancer
- Autorzy:
-
Pryczynicz, A.
Gryko, M.
Dymicka-Piekarska, V.
Lewczuk, Ł.
Wakulewska, A.
Ozimkiewicz, M.
Lebelt, A.
Guzińska-Ustymowicz, K. - Powiązania:
- https://bibliotekanauki.pl/articles/1917768.pdf
- Data publikacji:
- 2016
- Wydawca:
- Uniwersytet Medyczny w Białymstoku
- Tematy:
-
Colorectal cancer
matrix metalloproteinases
MMP-2
TIMP-2
serum marker - Opis:
- Purpose: To evaluate the clinical significance of MMP-2 and TIMP-2 concentrations in the sera of patients diagnosed with colorectal cancer. Methods: The study group comprised 48 patients with colorectal carcinoma and 24 healthy controls. The serum concentration of MMP-2 and TIMP-2 proteins was evaluated by the ELISA method. Results: The mean level of MMP-2 in the sera of patients with colorectal cancer was 39.4 ng/ml and was significantly lower compared with the control (p<0.001). A decrease in TIMP-2 protein in the sera of patients with colorectal cancer was also observed where its mean level was 132.3 ng/ml. The concentration of MMP-2 and TIMP-2 did not correlated with any clinicopathological parameters, except for the patients’ age. In addition, the concentration of MMP-2 in the sera of patients with CRC correlated negatively with the number of white blood cells in the blood and the prothrombin index. The concentration of TIMP-2 correlated positively with potassium and urea concentration in the blood. Conclusions: The results of our study indicate lack of clinical usefulness of determining the levels of MMP-2 and TIMP-2 in the sera of patients with colorectal cancer. However, these proteins play an important role in the carcinogenesis of colorectal cancer.
- Źródło:
-
Progress in Health Sciences; 2016, 6(1); 32-39
2083-1617 - Pojawia się w:
- Progress in Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł