Autor: Gromadzińska, Jolanta - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A seleno enzyme, glutathione peroxidase from human placenta: Purification and some properties
Peroksydaza głutationowa selenozależny enzym z łożyska ludzkiego: oczyszczanie i niektóre właściwości
Autorzy:: Gromadzinska, Jolanta
Zachara, Bronisław A
Powiązania:: https://bibliotekanauki.pl/articles/944964.pdf
Data publikacji:: 1992
Wydawca:: Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Źródło:: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1992, 9
0208-614X
Pojawia się w:: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Reference genes for gene expression studies on non-small cell lung cancer
Autorzy:: Gresner, Peter
Gromadzinska, Jolanta
Wasowicz, Wojciech
Powiązania:: https://bibliotekanauki.pl/articles/1040589.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: non-small cell lung cancer
reference genes
data normalization
real-time PCR
gene expression
Opis:: Study Objective: The aim of this study was to test a panel of 6 reference genes in order to identify and validate the most suitable reference genes for expression studies in paired healthy and non-small cell lung cancer tissues. Method: Quantitative real-time PCR followed by the NormFinder- and geNorm-based analysis was employed. The study involved 21 non-small cell lung cancer patients. Results: The analysis of experimental data revealed HPRT1 as the most stable gene followed by RPLP0 and ESD. In contrast, GAPDH was found to be the least stable gene. HPRT1 together with ESD was revealed as the pair of genes introducing the least systematic error into data normalization. Validation by bootstrap random sampling technique and by normalizing exemplary gene expression data confirmed the results. Conclusion: Although HPRT1 and ESD may by recommended for data normalization in gene expression studies on non-small cell lung cancer, the suitability of selected reference genes must be unconditionally validated prior to each study.
Źródło:: Acta Biochimica Polonica; 2009, 56, 2; 307-316
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase
Autorzy:: Zachara, Bronislaw
Gromadzinska, Jolanta
Zbrog, Zbigniew
Swiech, Rafal
Wasowicz, Wojciech
Twardowska, Ewa
Jablonska, Ewa
Sobala, Wojciech
Powiązania:: https://bibliotekanauki.pl/articles/1040656.pdf
Data publikacji:: 2009
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: hemodialysis
selenium supplementation
glutathione peroxidase
chronic kidney disease
plasma
Opis:: Background: Numerous authors have shown that selenium (Se) concentration and glutathione peroxidase (GSH-Px) activity in plasma of chronic kidney disease (CKD) patients are lower than in healthy subjects, but there are only few publications on the level of GSH-Px protein in those patients and no reports on the effect of Se supplementation to HD patients on the level of this enzyme. Subjects and Methods: Se concentration and GSH-Px protein level in plasma were measured in a group of 30 CKD patients on hemodialysis (HD) supplemented with 200 µg Se/day for 3 months, and 28 patients on HD administered with placebo. Se concentration was measured by graphite furnace atomic absorption spectrometry and plasma GSH-Px protein level by the sandwich ELISA method using polyclonal antibody specific for human plasma GSH-Px. Results: Se concentration in patients on placebo did not change throughout the 3-month study period, but increased significantly in Se supplemented group. Se supplementation to CKD patients on HD had no effect on the level of GSH-Px protein. Conclusions: The lack of GSH-Px protein in CKD patients on HD is not linked to Se deficiency since the level of this element increased after Se supplementation while enzyme protein level did not change. The damaged kidney of HD patients is unable to synthesize GSH-Px, even after induction with selenium.
Źródło:: Acta Biochimica Polonica; 2009, 56, 1; 183-187
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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