- Tytuł:
- 4-Week inhalation toxicity of 2-methylnaphthalene in experimental animals
- Autorzy:
-
Świercz, Radosław
Wąsowicz, Wojciech
Stetkiewicz, Jan
Gromadzińska, Jolanta
Majcherek, Wanda - Powiązania:
- https://bibliotekanauki.pl/articles/2185378.pdf
- Data publikacji:
- 2011-12-01
- Wydawca:
- Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
- Tematy:
-
2-Methylnaphthalene
rats
inhalation
NOAEL
LOAEL - Opis:
- Objectives: This paper presents toxic effects of 2-MN in laboratory animals under conditions of 4-week inhalation exposure to 2-methylnaphthalene (2-MN) vapors. Materials and Methods: Male Wistar rats were exposed to 2-MN vapors at a nominal concentration of 0, 2, 10 or 50 mg/m³ in dynamic inhalation chambers for 4 weeks (6 h/day, 5 days/week). After 4 weeks of inhalation exposure the animals were necropsied. Blood samples were collected and selected organs were weighted and prepared for histological examinations. Results: The effects of the increased levels of exposure to 2-MN experienced by the experimental rats were as follows: a) increasing γ-glutamylotransferase activity, b) stimulation of the hematopoietic system, c) lower cholesterol concentrations, d) higher number of goblet cells in lobar bronchi, e) hyperplasia of hepatic bile ducts. Conclusion: Four-week exposure of the animals to 2-MN at 2 mg/m³ proved to be the no-observed-adverse-effect-level (NOAEL), while 10 mg/m³ appeared to represent the lowest-observed-adverseeffect- level (LOAEL).
- Źródło:
-
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 4; 399-408
1232-1087
1896-494X - Pojawia się w:
- International Journal of Occupational Medicine and Environmental Health
- Dostawca treści:
- Biblioteka Nauki
Artykuł