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Wyświetlanie 1-2 z 2
Tytuł:
Characterisation and dissolution properties of ketoprofen in binary solid dispersion with chitosan
Autorzy:
Grimling, Bożena
Górniak, Agata
Meler, Jan
Szcześniak, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1035185.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
different molecular weights of chitosan
dissolution
ketoprofen
solid dispersion prepared solvent evaporation
Opis:
BCS class II includes drugs with low solubility and high permeability. Ketoprofen is an example of this class of drugs. The aim of the study was to investigate the effect of chitosan with average molecular weights in various formulations on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in solid dispersions using a method of the solvent evaporations at the drug to polymer ratios of 1:9. 3:7, and 5:5. The highest dissolution of fenofibrate, amounting to 98.8%, was observed after 60 minutes from solid dispersions with a drug-polymer weight ratio 1:9 in the presence of chitosan B and was 32-times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. DSC and IR investigations showed that ketoprofen remained in its crystalline state in solid dispersion. There was no change in the chemical structure of the drug after the incorporation of the drug onto the polymer. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 23-31
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of the physicochemical factors on dissolution of the substance of class ii bcs from solid dispersions with chitosan
Autorzy:
Grimling, Bożena
Górniak, Agata
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1035331.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
different molecular weights of chitosan
fenofibrate
solid dispersion prepared solvent evaporation
solubility
Opis:
The BCS class II includes drugs with low solubility and high permeability. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan about average molecular weight in various formulations on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporations at the drug to polymer ratio of 1:9;3:7;5:5. The highest dissolution of fenofibrate, amounting to 72.7%, was observed after 60 minutes from solid dispersions with drug-polymer weight ratio 1:9 in the presence chitosan A and was72 times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. Investigations DSC showed that fenofibrate was remained in crystalline state in solid dispersion.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 157-165
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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