Wszystkie pola: Physicochemical - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The study of physicochemical properties of solid dispersions of ibuprofen in the presence of chitosan
Autorzy:: Grimling, Bożena
Meler, Jan
Szcześniak, Maria
Pluta, Janusz
Górniak, Agata
Powiązania:: https://bibliotekanauki.pl/articles/1034797.pdf
Data publikacji:: 2015
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:: chitosan
dissolution
ibuprofen
solid dispersion
Opis:: The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
Źródło:: Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 64-72
1896-5644
Pojawia się w:: Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Physicochemical characterization and dissolution studies of solid dispersions of clotrimazole with chitosan
Autorzy:: Grimling, Bożena
Jasińska, Justyna
Meler, Jan
Szcześniak, Maria
Pluta, Janusz M.
Górniak, Agata
Powiązania:: https://bibliotekanauki.pl/articles/1034642.pdf
Data publikacji:: 2016
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:: FTIR
XRPD
chitosan
clotrimazole
solid dispersion
Opis:: The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.
Źródło:: Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 63-72
1896-5644
Pojawia się w:: Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
Autorzy:: Szcześniak, Maria
Grimling, Bożena
Meler, Jan
Pluta, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1034687.pdf
Data publikacji:: 2016
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:: Carbopl 934P
PVP
chitosane
hydrogels
pharmaceutical availability
rheological parameters
Opis:: The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
Źródło:: Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
1896-5644
Pojawia się w:: Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Evaluation of physicochemical properties of solid dispersions of bcs class ii substances with chitosan
Autorzy:: Grimling, Bożena
Górniak, Agata
Meler, Jan
Pluta, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1035366.pdf
Data publikacji:: 2012
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:: DSC studies
chitosan
dissolution
fenofibrate
solid state lyophilisation
Opis:: The BCS class II includes drugs with low solubility and high permeability. The substances require modification to increase their solubility in the upper part of the digestive system. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation by means of freeze-drying at the drug to polymer ratio of 3:7,5:5,7:3. The study revealed a multi-fold increase (from 33 to 57 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. DSC examination revealed a possible physical interaction between the drug and the polymer. The degree of lowering of temperature and increased heat effects is correlated with increased solubility of the drug in all the formulations. DSC studies confirmed that fenofibrate is present in solid dispersions in a crystalline form.
Źródło:: Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 87-94
1896-5644
Pojawia się w:: Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: The investigation of physicochemical properties of the solid dispersions in the presence polymeric carrier- chitosan
Autorzy:: Grimling, Bożena
Meler, Jan
Pluta, Janusz
Górniak, Agata
Powiązania:: https://bibliotekanauki.pl/articles/1035561.pdf
Data publikacji:: 2013
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:: DSC
IR studies
chitosan
fenofibrate
physical mixtures
saturation solubility
solid dispersions
Opis:: The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
Źródło:: Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 167-173
1896-5644
Pojawia się w:: Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: The influence of the physicochemical factors on dissolution of the substance of class ii bcs from solid dispersions with chitosan
Autorzy:: Grimling, Bożena
Górniak, Agata
Meler, Jan
Pluta, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1035331.pdf
Data publikacji:: 2013
Wydawca:: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:: different molecular weights of chitosan
fenofibrate
solid dispersion prepared solvent evaporation
solubility
Opis:: The BCS class II includes drugs with low solubility and high permeability. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan about average molecular weight in various formulations on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporations at the drug to polymer ratio of 1:9;3:7;5:5. The highest dissolution of fenofibrate, amounting to 72.7%, was observed after 60 minutes from solid dispersions with drug-polymer weight ratio 1:9 in the presence chitosan A and was72 times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. Investigations DSC showed that fenofibrate was remained in crystalline state in solid dispersion.
Źródło:: Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 157-165
1896-5644
Pojawia się w:: Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:: Biblioteka Nauki

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