- Tytuł:
- Increased levels of antibodies against heat shock proteins in stroke patients
- Autorzy:
-
Banecka-Majkutewicz, Zyta
Grabowski, Michał
Kadziński, Leszek
Papkov, Aliaksei
Węgrzyn, Alicja
Banecki, Bogdan - Powiązania:
- https://bibliotekanauki.pl/articles/1039307.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
HSP
Heat Shock Proteins
Stroke
DnaK
DnaJ
GroEL
Hsp70
ELISA - Opis:
- Ischemic stroke is the second leading cause of death worldwide. One of the main risk factors of the ischemic stroke is atherosclerosis which is a chronic inflammatory and immune-mediated disease. Bacterial infections generate specific human antibodies against various antigens, including Hsps. It has been demonstrated that Hsps are selectively overexpressed in the atherosclerotic lesions. The amino acid sequence homology between human and bacterial Hsps may lead to an autoimmune response by immunological cross-reaction. Such immune response against Hsps overexpressed in the blood vessels under stressful conditions may contribute to inflammatory processes and subsequent development of atherosclerosis. In this study we determined the antibody levels against bacterial and human Hsp by ELISA in blood plasma obtained from stroke patients. Using ANOVA we analyzed levels of Hsp-antibodies in control and patient groups and correlate them with several stroke risk factors. The group of stroke patients had elevated levels of anti-Hsp antibodies compared to the control group. We also discovered an antibody level increase in patients that previously underwent another stroke. Our data provide evidence that autoimmunity could underlie formation of atherosclerosis plaque leading to stroke.
- Źródło:
-
Acta Biochimica Polonica; 2014, 61, 2; 379-383
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł