- Tytuł:
-
Charakterystyka mikrobiologiczna i kliniczna grzybów z rodzaju Malassezia
Microbiological and clinical characteristics of Malassezia fungi - Autorzy:
-
Gnat, Sebastian
Łagowski, Dominik - Powiązania:
- https://bibliotekanauki.pl/articles/22180792.pdf
- Data publikacji:
- 2021
- Wydawca:
- Krajowa Izba Lekarsko-Weterynaryjna
- Tematy:
-
grzyby
Malassezia
charakterystyka
taksonomia
hodowla laboratoryjna
identyfikacja
chorobotwórczość
wrażliwość na leki
diagnostics
pathogenicity
treatment
hosts
lipid dependency - Opis:
- Fungi classified into the genus Malassezia, are opportunistic pathogens with high clinical importance in veterinary medicine. The major disease entities associated with these yeasts, include dermatological conditions, e.g. otitis externa, pododermatitis, and dermatitis seborrhoica. Fungi from the genus Malassezia have a wide species-specific range of hosts, where they are present in either commensal or infectious state. There is a number of scientific reports describing diseases caused by these yeasts in cats, dogs, horses, goats, pigs and rabbits. To date, 18 species have been identified, including 17 lipid-dependent and 1 lipid-independent species, with M.pachydermatis isolated from animals most frequently. The lipid dependency of Malassezia spp., results from their inability to synthesize myristic acid, which is a precursor of long-chain fatty acids. The dimorphic Malassezia fungi can occur in natural conditions in both mycelial and yeast phases. In turn, the yeast stage dominates, when they are cultivated under in vitro conditions. The fungus reproduces by budding on a wide base from the same site on one pole (unipolar blastic growth); hence, yeast-like cells in vitro resemble bottles. The recommended treatment of these fungal infections is based on the use of shampoo with 2% miconazole and 2% chlorhexidine, twice a week. Additionally, as shown by research data, itraconazole and ketoconazole have high in vitro efficacy against all Malassezia species, whereas fluconazole and voriconazole exert a very weak effect. In this article a current research is presented, that is focused on the sequence analysis of the genomes of different Malassezia species, which may provide key information required for faster diagnosis, elucidation of the biochemical mechanisms of skin adaptation, and formulation of new drugs.
- Źródło:
-
Życie Weterynaryjne; 2021, 96, 03; 179-186
0137-6810 - Pojawia się w:
- Życie Weterynaryjne
- Dostawca treści:
- Biblioteka Nauki
Artykuł