- Tytuł:
- Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.
- Autorzy:
-
Ciarkowski, Jerzy
Drabik, Piotr
Giełdoń, Artur
Kaźmierkiewicz, Rajmund
Ślusarz, Rafał - Powiązania:
- https://bibliotekanauki.pl/articles/1044085.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
signal transduction
neurohypophyseal receptors
molecular modeling
GPCRs - Opis:
- G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 4; 1203-1207
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł