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    Wyświetlanie 1-3 z 3
    Tytuł:
    Navigation of autonomous mobile robot using different activation functions of wavelet neural network
    Autorzy:
    Panigrahi, P. K.
    Ghosh, S.
    Parhi, D. R.
    Powiązania:
    https://bibliotekanauki.pl/articles/229613.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    autonomous mobile robot
    activation functions
    obstacle avoidance
    path planning
    wavelet neural network
    Opis:
    An autonomous mobile robot is a robot which can move and act autonomously without the help of human assistance. Navigation problem of mobile robot in unknown environment is an interesting research area. This is a problem of deducing a path for the robot from its initial position to a given goal position without collision with the obstacles. Different methods such as fuzzy logic, neural networks etc. are used to find collision free path for mobile robot. This paper examines behavior of path planning of mobile robot using three activation functions of wavelet neural network i.e. Mexican Hat, Gaussian and Morlet wavelet functions by MATLAB. The simulation result shows that WNN has faster learning speed with respect to traditional artificial neural network.
    Źródło:
    Archives of Control Sciences; 2015, 25, 1; 21-34
    1230-2384
    Pojawia się w:
    Archives of Control Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design, molecular docking, drug-likeness, and molecular dynamics studies of 1,2,4-trioxane derivatives as novel Plasmodium falciparum falcipain-2 (FP-2) inhibitors
    Autorzy:
    Ghosh, S.
    Chetia, D.
    Gogoi, N.
    Rudrapal, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096418.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    1
    2
    4-trioxane
    Plasmodium falciparum
    drug resistance
    molecular docking
    molecular dynamics
    falcipain 2 inhibitors
    Opis:
    Despite significant progress made in drug discovery and development over the past few decades, malaria remains a life-threatening infectious disease across the globe. Because of the widespread emergence of drug-resistant strains of Plasmodium falciparum, the clinical utility of existing drug therapies including Artemisinin-based Combination Therapies (ACTs) in the treatment of malaria has been increasingly limited. It has become a serious health concern which, therefore, necessitates the development of novel drug molecules and/or alternative therapies to combat, particularly resistant P. falciparum. The objective of the present study was to develop 1,2,4-trioxane derivatives as novel antimalarial agents that would be effective against resistant P. falciparum. In our study, 15 new trioxane derivatives were designed by molecular modification of the 1,2,4-trioxane scaffold as possible antimalarial agents. Molecular modeling studies of trioxane derivatives were performed based on the CADD approach using Biovia Discovery Studio (DS) 2018 software. The protein-ligand docking study was performed against P. falciparum falcipain 2 (FP-2) using the simulation-based docking protocol LibDock by the flexible docking method. The assessment of drug-likeness, ADMET properties, and toxicity was also performed. Furthermore, the compounds CC3 and CC7, which showed the best binding affinity against the target P. falciparum FP-2, were investigated by molecular dynamics (MD) simulation studies followed by the calculation of MM-PBSA binding free energy of protein-ligand complexes using DS 2020. Results of the docking study showed that among the 15 compounds, three trioxane derivatives were found to possess promising binding affinity with LibDock scores ranging from 117.16 to 116.90. Drug-likeness, ADMET, and toxicity properties were found to be satisfactory for all the compounds. Among the 15 compounds, two compounds, namely CC3 and CC7, showed the highest binding affinity against FP-2 with LibDock score of 117.166 and 117.200, respectively. The Libdock score of the co-crystal inhibitor was 114.474. MD studies along with MM-PBSA calculations of binding energies further confirmed the antimalarial potential of the compounds CC3 and CC7, with the formation of well-defined and stable receptor-ligand interactions against the P. falciparum FP-2 enzyme. Additionally, the selectivity of trioxane hits identified as potential inhibitors of P. falciparum cysteine protease FP-2 was determined on human cysteine proteases such as cathepsins (Cat K and Cat L), which are host homologous. Finally, it was concluded that the newly designed 1,2,4-trioxane derivatives can be further studied for in vitro and in vivo antimalarial activities for their possible development as potent antimalarial agents effective against resistant P. falciparum
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 257-275
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of viable fungi in indoor air: a case study from Tagore’s residence at Jorasanko, India
    Autorzy:
    Bhattacharyya, S.
    Mukherjee, D.
    Sarkar, P.
    Ghosh, S.
    Samaddar, B.
    Chaudhuri, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/11560.pdf
    Data publikacji:
    2015
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    assessment
    viable fungi
    fungi
    indoor air
    indoor environment
    Tagore’s residence
    Jorasanko
    India
    Opis:
    Indoor environment is significant with respect to human health especially if it is concerned when the building is v. Aim of very old. In the present study was to assess the presence of airborne fungi at an old building in Kolkata India where lots of tourists are exposed every day. Residence of famous Nobel laureate poet Rabindranath Tagore (built in the 18th century and presently used as a famous museum) in Kolkata, West Bengal was selected for this study and the indoor fungi from different room of the museum were assessed by using exposure plate technique. Humidity, temperature, wind speed and illuminance were also measured by hygrometer, thermometer anemometer and lux-meter respectively. The fungal species isolated from the air samples of different rooms were Aspergillus sp., Penicillium sp., Paecilomyces sp., Trichoderma sp, Alternaria sp Verticillium sp, Fusarium sp, Cladosporium sp, Yeast, Curvularia sp. and Helminthosporium sp. among them, Aspergillus sp. (71.4% at monsoon at library), Penicillium sp (57% at summer at library), Paecilomyces sp.(91% at monsoon at manuscript room) are mostly dominated pathogens, which may harm the workers and visitors of the museum. No significant correlation among colony forming unit of fungi with illuminance, wind speed and temperature in the tested indoor environment was noted whereas, the humidity in indoor environment played a crucial (P<0.05) role. Round the year humidity control may be required for maintaining healthy environment.
    Źródło:
    International Letters of Natural Sciences; 2015, 06
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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