- Tytuł:
- Esculetin Attenuates Neurotoxicity Induced by Aβ25-35 in SH-SY5Y Cells via inhibiting Oxidative Stress and Mitochondria-mediated Apoptosis
- Autorzy:
-
Gao, Jun-Li
Gong, Xiao-Ying - Powiązania:
- https://bibliotekanauki.pl/articles/895539.pdf
- Data publikacji:
- 2018-10-31
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
apoptosis
oxidative stress
Alzheimer’s disease
esculetin
SH-SY5Y cells - Opis:
- Alzheimer’s disease (AD) is a neurodegenerative disease afflicting many people worldwide. As the specific biomarker, beta amyloid (Aβ) is considered to serve a central role in the progress of AD. To discover effective therapy for AD, esculetin was investigated using SH-SY5Y cells to evaluate its protective effects against the neurotoxicity induced by Aβ25-35. As a result, esculetin can improve the viability of SH-SY5Y cells injured by Aβ25-35 (58.0%, 66.1% and 82.1% at 0.1, 1 and 10 μM vs 49.5% at 0 μM). Further investigation has demonstrated the protective effects of esculetin at different concetrations of 0.1, 1 and 10 μM are associated with its inhibition of oxidative stress and apoptosis in SH-SY5Y cells, which is more observable especially at both 1 and 10 μM. These observations can give evidences for the following investigation in vivo and discovery of novel preventive method for AD.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1177-1185
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł