Autor: Rudnicka, K. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Genotoxicity of cyclopentha[c]phenanthrene and its two derivatives based on an in vitro micronucleus test
Autorzy:: Rudnicka, K.
Łuczyński, M. K.
Góra, M.
Powiązania:: https://bibliotekanauki.pl/articles/363298.pdf
Data publikacji:: 2012
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:: derivatives
genotoxicity
in vitro micronucleus test
PAHs
V79
pochodne
genotoksyczność
test mikrojądrowy in vitro
Opis:: Environmental pollution causes a variety of health problems, including cancer. Many known pollutants have carcinogenic properties and polycyclic aromatic hydrocarbons (PAH) belong to this group. In this study, an in vitro culture of V79 cells of the Chinese hamster was subjected to three tested PAHs: 5-amino-2,3-dihydro-1H-cyclopenta-[c]phenanthrene (ACP[c]Ph), 5-amino-9-methoxy-2,3-dihydro-1H-cyclopenta[c]phenanthrene (AMCP[c]Ph) and cyclopenta[c]phenanthrene (CP[c]Ph). The in vitro micronucleus (MN) assay was applied in order to evaluate the genotoxic properties of the studied compounds. The highest genotoxic effect was observed for AMCP[c]Ph in a concentration of 0.02μg·ml-1. The genotoxic effect of the other two compounds was slightly lower.
Źródło:: Environmental Biotechnology; 2012, 8, 2; 63-66
1734-4964
Pojawia się w:: Environmental Biotechnology
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Assessment of mutagenic activity of methyl- and phenylphenanthrenes based on Salmonella test and micronucleus test
Autorzy:: Rudnicka, K.
Tejs, S.
Budzikur, K. A.
Mielżyńska-Švach, D.
Jakimiuk, E.
Chachaj, A.
Góra, M.
Żelazna, K.
Łuczyński, M. K.
Powiązania:: https://bibliotekanauki.pl/articles/363178.pdf
Data publikacji:: 2013
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:: Ames test
in vitro
micronucleus test
mutagenicity
phenanthrene
test Amesa
mutagenność
test mikrojądrowy
fenanatren
Opis:: Polycyclic aromatic hydrocarbons (PAHs) are widely spread environmental pollutants mainly originating from anthropogenic sources such as fossil fuel combustion, industries, and others. Although a large body of literature exists on the toxicity and carcinogenicity of PAHs, primarily benzo[a]pyrene, toxicity data for phenanthrene deriveratives are very limited. The main aim of the experiment was to investigate if there exists correlation between molecular structure and mutagenic activity of four phenanthrene derivatives: 1 methylphenanthrene, 4 methylphenanthrene, 1 phenylphenanthrene, and 4 phenylphenanthrene. An Ames assay using two strains of histidine dependent Salmonella Typhimurium (TA98 and TA100) was conducted to assess the mutagenic activity of studied compounds both in the presence (+S9) and in the absence (-S9) of an exogenous source of metabolic activation. The compounds were also tested in an in vitro chromosome aberration assay in which V-79 cells were exposed to the phenanthrene derivatives investigated both in the presence and in the absence of metabolic activation. The phenylphenanthrenes showed no mutagenic effect. These compounds occasionally induced significant decrease in the number of revertants in the Ames test. The greatest mutagenic effects were observed for 1 methylphenanthrene after metabolic activation (+S9). In the micronucleus test the greatest mutagenic effect was observed for 4 methylphenanthrene also in the presence of metabolic activation system. The results obtained are comparable to those reported earlier for the methylphenanthrenes.
Źródło:: Environmental Biotechnology; 2013, 9, 2; 65-71
1734-4964
Pojawia się w:: Environmental Biotechnology
Dostawca treści:: Biblioteka Nauki

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