Temat: hypothesis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Simultaneous testing procedures of many null hypotheses and their applications in the DNA microarrays analysis
Autorzy:: Dudziński, Marcin
Furmańczyk, Konrad
Powiązania:: https://bibliotekanauki.pl/articles/748330.pdf
Data publikacji:: 2007
Wydawca:: Polskie Towarzystwo Matematyczne
Tematy:: Multiple hypothesis testing procedures, Familywise error rate, False discovery proportion, False discovery rate, p-values, q-values, DNA microarrays
Opis:: W naszej pracy rozważamy różne podejścia do problematyki jednoczesnego testowania wielu hipotez zerowych. W tym kontekście omawiamy procedury testowania typu single-step, step-down i step-up. W szczególności, przedstawiamy własności i zastosowania takich miar błędów testowania, jak: FWER, k-FWER, FDP, FDR, pFDR. Wspomniane procedury testowania są intensywnie wykorzystywane w analizie mikromacierzy DNA, która to analiza umożliwia monitorowanie poziomów ekspresji wielu genów jednocześnie oraz znajduje ostatnio szerokie zastosowania w diagnostyce, leczeniu i badaniach medycznych.
In our paper, we consider different approaches to the problem of simultaneous testing of many null hypotheses. In this context, we discuss the single-step, the step-down and the step-up procedures of multiple testing. In particular, we are concerned with their properties and applications in the control of the error rates, such as:FW ER, k-FWER, FDP, FDR, pFDR. The mentioned procedures are intensively used in the DNA microarrays analysis, which enables the monitoring of expression levels of many genes simultaneously and is widely applied in recent medical diagnostics, treatment and research.
Źródło:: Mathematica Applicanda; 2007, 35, 49/08
1730-2668
2299-4009
Pojawia się w:: Mathematica Applicanda
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Evaluation of selected aspects of the hygiene hypothesis and their effect on the incidence of allergy
Autorzy:: Krzych-Fałta, Edyta
Wojas, Oksana
Furmańczyk, Konrad
Dziewa-Dawidczyk, Diana
Piekarska, Barbara
Samoliński, Bolesław
Sybilski, Adam
Powiązania:: https://bibliotekanauki.pl/articles/2188907.pdf
Data publikacji:: 2023
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: asthma
allergy
allergic rhinitis
hygiene hypothesis
European Community Respiratory Health Survey II
International Study of Asthma and Allergies in Childhood
Opis:: Objectives The development of allergic conditions is largely dependent on the interactions between genetic (individual genetic predisposition) and environmental factors (exposure to risk factors). The aim of this study was an attempt to assess the influence of selected elements of the hygiene theory in the development of allergic diseases such as allergic rhinitis and asthma. Material and Methods The study group consisted of 5518 women and 3868 men. The method that was used was the European Community Respiratory Health Survey II and International Study of Asthma and Allergies in Childhood questionnaire validated and adapted to Central and Eastern European conditions. The project was conducted in 8 urban areas (Gdańsk, Wrocław, Poznań, Katowice, Kraków, Lublin, Białystok, Warsaw) and 1 rural area (Krasnystaw county). This study had 2 stages; the first stage involved grouping the 22 500 respondents based on their questionnaire responses with the use of a Personal Digital Assistant (PDA); the second stage involved 7000 subjects, who underwent additional assessments: skin prick tests (birch, grasses/cereals, Dermatophagoides pteronyssinus and Dermatophagoides farinae, molds [set I: Botrytis cinerea, Cladosporium herbarum, Alternaria tenuis, Curvularia lunata, Fusarium moniliforme, Helminthosporium], molds [set II: Aspergillus fumigatus, Mucor mucedo, Penicillium notatum, Pullularia pullulans, Rhizopus nigricans, Serpula lacrymans], cat, dog, molds Cladosporium herbarum, Alternaria tenuis) and spirometry tests. Results The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05). Conclusions The hygiene theory is particularly applicable and can explain the relationship of selected habits in the development of allergic diseases.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2023, 36, 1; 69-83
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Evaluation of selected aspects of the hygiene hypothesis and their effect on the incidence of allergy
Autorzy:: Krzych-Fałta, Edyta
Wojas, Oksana
Furmańczyk, Konrad
Dziewa-Dawidczyk, Diana
Piekarska, Barbara
Samoliński, Bolesław
Sybilski, Adam
Powiązania:: https://bibliotekanauki.pl/articles/2203019.pdf
Data publikacji:: 2023-03-02
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: asthma
allergy
allergic rhinitis
hygiene hypothesis
European Community Respiratory Health Survey II
International Study of Asthma and Allergies in Childhood
Opis:: Objectives The development of allergic conditions is largely dependent on the interactions between genetic (individual genetic predisposition) and environmental factors (exposure to risk factors). The aim of this study was an attempt to assess the influence of selected elements of the hygiene theory in the development of allergic diseases such as allergic rhinitis and asthma. Material and Methods The study group consisted of 5518 women and 3868 men. The method that was used was the European Community Respiratory Health Survey II and International Study of Asthma and Allergies in Childhood questionnaire validated and adapted to Central and Eastern European conditions. The project was conducted in 8 urban areas (Gdańsk, Wrocław, Poznań, Katowice, Kraków, Lublin, Białystok, Warsaw) and 1 rural area (Krasnystaw county). This study had 2 stages; the first stage involved grouping the 22 500 respondents based on their questionnaire responses with the use of a Personal Digital Assistant (PDA); the second stage involved 7000 subjects, who underwent additional assessments: skin prick tests (birch, grasses/cereals, Dermatophagoides pteronyssinus and Dermatophagoides farinae, molds [set I: Botrytis cinerea, Cladosporium herbarum, Alternaria tenuis, Curvularia lunata, Fusarium moniliforme, Helminthosporium], molds [set II: Aspergillus fumigatus, Mucor mucedo, Penicillium notatum, Pullularia pullulans, Rhizopus nigricans, Serpula lacrymans], cat, dog, molds Cladosporium herbarum, Alternaria tenuis) and spirometry tests. Results The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05).The age at which children attend the nursery school is critical to the development of allergic diseases; in allergic rhinitis, the risk of an IgE-dependent reaction is 2 times higher in the second than in the first year of life (p = 0.00147, p < 0.05), while in asthma, having a large number of siblings increases the risk of developing obstructive disease by almost 6 times (p = 0.00316, p < 0.05). Conclusions The hygiene theory is particularly applicable and can explain the relationship of selected habits in the development of allergic diseases. Int J Occup Med Environ Health. 2023;36(1):69–83
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2023, 36, 1; 69-83
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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