- Tytuł:
- Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro
- Autorzy:
-
Luty, Marcin
Kwiecień, Edyta
Firlej, Magdalena
Łabędź-Masłowska, Anna
Paw, Milena
Madeja, Zbigniew
Czyż, Jarosław - Powiązania:
- https://bibliotekanauki.pl/articles/1038754.pdf
- Data publikacji:
- 2016
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
carcinosarcoma
mitoxantrone
curcumin
apoptosis
motility - Opis:
- Numerous adverse effects limit the applicability of mitoxantrone for the treatment of drug-resistant tumors, including carcinosarcoma. Here, we estimated the additive effects of mitoxantrone and curcumin, a plant-derived biomolecule isolated from Curcuma longa, on the neoplastic and invasive potential of carcinosarcoma cells in vitro. Curcumin augmented the cytostatic, cytotoxic and anti-invasive effects of mitoxantrone on the Walker-256 cells. It also strengthened the inhibitory effects of mitoxantrone on the motility of drug-resistant Walker-256 cells that had retained viability after a long-term mitoxantrone/curcumin treatment. Thus, curcumin reduces the effective doses of mitoxantrone and augments its interference with the invasive potential of drug-resistant carcinosarcoma cells.
- Źródło:
-
Acta Biochimica Polonica; 2016, 63, 3; 397-401
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł