- Tytuł:
- Minimal state automata for detecting a β globin gene mutation
- Autorzy:
-
Ferdania, Devi Fitri
Irawati, -
Garminia, Hanni
Akhmaloka, -
Rachmansyah, Kemal Aziez - Powiązania:
- https://bibliotekanauki.pl/articles/1838203.pdf
- Data publikacji:
- 2021
- Wydawca:
- Uniwersytet Zielonogórski. Oficyna Wydawnicza
- Tematy:
-
minimal state automata
syntactic monoid
β-thalassemia
biological sequences
automat stanu minimalnego
monoid syntaktyczny
sekwencja biologiczna - Opis:
- Beta-thalassemia is an autosomal recessive blood disorder characterized by abnormalities in the synthesis of β globin. Together with α globin, it is a subunit of globin protein, called hemoglobin, located inside our red blood cells to deliver oxygen from the lungs to all of the tissues throughout our body. Thereby, individuals with β-thalassemia will often feel limp due to a lack of oxygen dissolved in their blood. In this paper, a finite state automaton to detect and classify β globin gene mutations using its DNA sequence is constructed. Finite state automata have a close connection to an algebraic structure, that is, a monoid. Together with the theory of the syntactic monoid, we present a methodology to minimize the number of the internal states of an automaton to have minimal state automata. Therefore, a minimal state automaton can be constructed to detect β globin gene mutation causing the β-thalassemia disease. We have developed a MATLAB program to conduct the appropriate simulations.
- Źródło:
-
International Journal of Applied Mathematics and Computer Science; 2021, 31, 2; 337-351
1641-876X
2083-8492 - Pojawia się w:
- International Journal of Applied Mathematics and Computer Science
- Dostawca treści:
- Biblioteka Nauki
Artykuł