- Tytuł:
- NLCs as a potential carrier system for transdermal delivery of forskolin
- Autorzy:
-
Lasoń, Elwira
Sikora, Elżbieta
Miastkowska, Małgorzata
Escribano, Elvira
Garcia-Celma, Maria
Solans, Conxita
Llinas, Meritxell
Ogonowski, Jan - Powiązania:
- https://bibliotekanauki.pl/articles/1038376.pdf
- Data publikacji:
- 2018
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
Forskolin
NLC
nanostructured lipid carrier
skin permeation - Opis:
- Nanostructured lipid carriers (NLC) composed of the substances generally recognized as safe (GRAS) were obtained by using a hot high-pressure homogenization technique (HPH). The influence of the number of homogenization cycles and concentration of a decyl glucoside surfactant on the NLC properties were studied. The system's stability was assessed by macroscopic observation, light backscattering and zeta potential measurements. NLC particle size was measured using dynamic light scattering (DLS). The kinetically stable formulations were loaded with forskolin and selected for in vitro drug permeation study using the Franz cell method. Concentration of forskolin in the receptor solution (i.e. ethanol/PBS mixture) was analyzed with high performance liquid chromatography (HPLC) with UV detection. The obtained results have shown that NLC formulations could be used as effective carriers for forskolin permeation through the skin.
- Źródło:
-
Acta Biochimica Polonica; 2018, 65, 3; 437-442
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł