- Tytuł:
- Up-regulation of human PNPase mRNA by β-interferon has no effect on protein level in melanoma cell lines
- Autorzy:
-
Gewartowski, Kamil
Tomecki, Rafal
Muchowski, Lukasz
Dmochowska, Aleksandra
Dzwonek, Artur
Malecki, Michal
Skurzak, Henryk
Ostrowski, Jerzy
Stepien, Piotr - Powiązania:
- https://bibliotekanauki.pl/articles/1041287.pdf
- Data publikacji:
- 2006
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
polynucleotide phosphorylase
melanoma
human mitochondria
beta interferon
poly(A) tails
PNPase - Opis:
- Human mitochondrial polynucleotide phosphorylase (hPNPase) is an exoribonuclease localized in mitochondria. The exact physiological function of this enzyme is unknown. Recent studies have revealed the existence of a relationship between induction of hPNPase mRNA and both cellular senescence and growth arrest of melanoma cells following β-interferon treatment. The aim of this study was to verify whether the augmented hPNPase mRNA level results in increase of the protein level. In several cell lines established from five metastatic melanoma patients we did not find any such correlation. However, an elevated level of hPNPase protein was observed in interferon-induced HeLa and Jurkat cells. This increase was correlated with a slight shortening of poly(A) tails of mitochondrial ND3 transcript.
- Źródło:
-
Acta Biochimica Polonica; 2006, 53, 1; 179-188
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł