- Tytuł:
- The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine
- Autorzy:
-
Leksa, Natalia
Pękala, Anna
Pardak, Piotr
Dziedzic, Rafał
Bartusik-Aebisher, Dorota
Filip, Rafał
Galiniak, Sabina
Aeisher, David - Powiązania:
- https://bibliotekanauki.pl/articles/454702.pdf
- Data publikacji:
- 2020-03-30
- Wydawca:
- Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
- Tematy:
-
13C NMR
dynamic nuclear polarization hyperpolarized carbon - Opis:
- Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine. Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
- Źródło:
-
European Journal of Clinical and Experimental Medicine; 2020, 1; 20-23
2544-2406
2544-1361 - Pojawia się w:
- European Journal of Clinical and Experimental Medicine
- Dostawca treści:
- Biblioteka Nauki
Artykuł