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    Wyświetlanie 1-8 z 8
    Tytuł:
    Zastosowanie związków kompleksowych platyny, palladu i kobaltu w medycynie. Cz. 1
    Application of coordination compounds of platinum, palladium and cobalt in medicine. Part 1
    Autorzy:
    Pawlak, Marta
    Drzeżdżon, Joanna
    Jacewicz, Dagmara
    Powiązania:
    https://bibliotekanauki.pl/articles/1409835.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki kompleksowe platyny
    związki kompleksowe palladu
    związki kompleksowe kobaltu
    leki przeciwnowotworowe
    coordination compounds of platinum
    coordination compounds of palladium
    coordination compounds of cobalt
    anticancer drugs
    Opis:
    The complex compounds containing metal ions are a group of compounds widely used in medicine. More and more metals are also being used to create cancer drugs or to help with other very serious diseases. Anticancer drugs are a particular use of complex compounds. Many thousands of platinum(II) compounds have been synthesized in cancer therapy, but only six of them have found use in the treatment of cancer. The most popular and the most commonly used compound is cisplatin, it has become the basis for the treatment of bladder, cervical, head, esophagus and many cancers occurring in children. The mechanism of action of platinum(II) and platinum(IV) compounds against cancer cells is to inhibit DNA replication, then RNA transcription and stop the G2 phase of the cell cycle and lead to programmed cell death or apoptosis. Coordination compounds containing more than one metal ion in their composition open new possibilities in the fight against cancer. Pt-DNA connections created by compounds containing at least two metal atoms are different from those formed by cisplatin. The basic dinuclear structure allows for great flexibility in forming DNA-DNA or DNA-protein bonds. The cobalt(III) complexes began to be used to image areas of hypoxia in cancer cells. It is believed, that cobalt(III) complexes undergo bioreduction, which leads to the release of the labile cobalt(II) complex and one or more bioactive ligands. Studies on nitro-Co(III) complexes containing acetylacetone and a nitrogen mustard ligand have shown that it is a particularly effective anti-cancer drug. Due to the fact that many people have cancer new effective anti-cancer drugs with low toxicity and no side effects are still being sought.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 11-12; 797-822
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Struktura i właściwości fizykochemiczne polimerów koordynacyjnych oraz materiałów typu MOF kadmu(II) i cynku(II)
    Structure and physicochemical properties of coordination polymers and MOF materials based on cadmium(II) and zinc(II)
    Autorzy:
    Pobłocki, Kacper
    Drzeżdżon, Joanna
    Jacewicz, Dagmara
    Powiązania:
    https://bibliotekanauki.pl/articles/1413238.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    polimery koordynacyjne
    sieci metaliczno-organiczne
    związki kadmu(II)
    związki cynku(II)
    MOF
    coordination polymer
    metal organic framework
    cadmium(II)
    compounds
    zinc(II) compounds
    Opis:
    In 1964, J.C. Bailat Jr. was one of the first scientists who use coordination polymers in his research. He established the rules of structure and the composition of compounds containing metal ions and organic ligands connected by coordination bonds to form layered or chain structures. He compared inorganic compounds belonging to polymeric species with organic polymers. The term Metal Organic Frameworks (MOF) was first used in the publication by О. M. Yaghia. Crystalline, microporous structures contain rigid organic ligands (used interchangeably: organic building blocks) that bind metal ions. This is called reticular synthesis. MOF surface area values usually range from 1000 to 10000 m2/g-1, thus exceeding the area values of traditional porous materials such as zeolites and carbons. Metal Organic Frameworks create porous three-dimensional structures, unlike coordination polymers. Inorganic minerals from the aluminosilicate group are used in the widespread heterogeneous catalysis and processes such as: adsorption and ion exchange, while compared to Metal Organic Frameworks, shows a lower potential than zeolites, moreover, the design of structures is less precise and rational due to the lack of shape, size and control functionalization of pores. To date, MOF are the most diverse and most numerous class of porous materials. All aspects have made them ideal structures for storing fuels such as hydrogen and methane. They are perfect for catalytic reactions and are good materials for capturing pollutants, e.g. CO2. The number of publications on coordination polymers (CP), Metal Organic Frameworks (MOF) or a group of hybrid compounds (organic-inorganic) increased tenfold at the turn of 2005, which proves the growing interest in this field by scientists around the world. MOF diversity in terms of structure, size, geometry, functionality and flexibility of MOF has led to the study of over 20,000 different MOF’s over the past decade. The search for new materials consists of combining molecular building blocks with the desired physicochemical properties. To produce a solid, porous material that can be used in the construction of a "molecular scaffold", rigid organic moieties, which are described in the literature as rods, must be combined with multi-core, inelastic inorganic clusters that act as joints (also called SBU secondary building units). By design, multi-core cluster nodes are able to impart thermodynamic stability through strong covalent bonds and mechanical stability due to coordination bonds that can stabilize the position of metals in the molecule. This property contrasts with those of the unstable single coordination polymers. The size and most importantly the chemical environment of the resulting voids are determined by the length and functions of the organic unit. Therefore, adjusting the appropriate properties of the material is made by appropriate selection of the starting materials. The isoretical method made it possible to use MOF structures with large pores (98 Á and low densities (0.13 g/cm3). This method involves changing the size and nature of Metal Organic Frameworks without changing the topology of their substrate. Thanks to this, it was possible to include large molecules such as vitamins (e.g. B12) or proteins (e.g. green fluorescence protein) into their structure and use the pores as reaction vessels. The thermal and chemical stability of many MOFs has made them amenable to functionalization by post-synthetic covalent organic complexes with metals. These properties make it possible to significantly improve gas storage in MOF structures and have led to their extensive research into the catalysis of organic reactions, activation of small molecules such as hydrogen, methane and water, gas separation, biomedical imaging and conductivity. Currently, methods of producing nanocrystals and MOF super crystals for their incorporation into specialized devices are being developed. Crystalline structures of MOF’s are formed by creating strong bonds between inorganic and organic units. Careful selection of MOF components produces crystals of giant porosity, high thermal and chemical stability. These features allow the interior of the MOF to be chemically altered to separate and store gases. The uniqueness of MOF materials is that they are the only solids to modify and increase the particle size without changing the substrate topology.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 1041-1073
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Właściwości katalityczne i biomedyczne związków zawierających jony rutenu (II) oraz Rutenu (III)
    Catalytic and biomedical properties of compound containing ruthenium (II) and ruthenium (III) ions
    Autorzy:
    Pobłocki, Kacper
    Pawlak, Marta
    Walczak, Juliusz
    Drzeżdżon, Joanna
    Jacewicz, Dagmara Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/27310039.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki kompleksowe Ru(II)
    związki kompleksowe Ru(III)
    właściwości biomedyczne
    właściwości katalityczne
    Ru(II) complex compounds
    Ru(III) complex compounds
    biomedical properties
    catalytic properties
    Opis:
    Ruthenium complexes appear in scientific publications mainly as catalysts in the olefins metathesis process. In this review, we want to indicate the research niche regarding the use of ruthenium(II) and ruthenium(III) complexes in other catalytic processes, i.e. polymerization or epoxidation of olefins and depolymerization. We would like to combine the catalytic properties of ruthenium(II,III) complex compounds with their biomedical activity due to the growing problem of drug resistance (including antibiotic resistance). Scientists have been designing new metallopharmaceuticals exhibiting biological activity for several years, therefore this requires a critical review of the literature. The main goal of designing new metallodrugs is to create compounds with new or stronger biological properties compared to free ligands. Ruthenium compounds are considered potential substitutes for known drugs. In particular, Ru(II) and Ru(III) based complexes have reduced toxicity and can be tolerated in vivo. In addition, a wide spectrum of ruthenium oxidation states, a different mechanism of action and the kinetics of ligand substitution increase the advantage over coordination complex compounds based on platinum. In conclusion, in this review, we will focus on the latest reports from the literature on the catalytic properties and biomedical activity of ruthenium(II) and ruthenium(III) chemical compounds.
    Źródło:
    Wiadomości Chemiczne; 2023, 77, 5-6; 569--595
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Związki wanadu i chromu jako potencjalne insulino-mime tyki wykorzystywane w leczeniu cukrzycy
    Vanadium and chromium compounds as the potential insulin-mimetics used in the treatment of diabetes
    Autorzy:
    Drzeżdżon, Joanna
    Malinowski, Jacek
    Zych, Dominika
    Jacewicz, Dagmara
    Powiązania:
    https://bibliotekanauki.pl/articles/972299.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki wanadu
    związki chromu
    działanie insulino-naśladowcze
    właściwości przeciwcukrzycowe
    leczenie cukrzycy u ludzi
    vanadium derivatives
    chromium derivatives
    insulin mimetic action
    antidiabetic properties
    human diabetic treatment
    Opis:
    The report focuses on the antidiabetic, also termed insulin-like, effect of various vanadium and chromium derivatives, proposed mechanisms of their activity, their use in in vivo and in vitro studies, as well as in diabetic patients, their toxicity and effectiveness in controlling clinical signs of diabetes. Studies indicate that compounds of vanadium and chromium is necessary for regulation of carbohydrate and lipid metabolism mainly due to increasing the number of insulin receptors and its activation by phosphorylation. Some authors believe that compounds of chromium(III) deficiency can lead to glucose intolerance and symptoms of type 2 diabetes. However, due to methodological limitations of many clinical studies, the statements of major diabetes associations concerning recommendation of various vanadium and chromium derivatives supplementation in individuals with diabetes and obesity still remains negative. Additional studies are urgently needed to elucidate the mechanism of action of chromium and vanadium compounds and its role in the prevention and control of diabetes.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 11-12; 753-775
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowanie związków kompleksowych rutenu, złota, wanadu, chromu, bizmutu, technetu w medycynie. Cz. 2
    Application of coordination compounds of ruthenium, gold, vanadium, chromium, bismuth, technetium in medicine. Part 2
    Autorzy:
    Pawlak, Marta
    Drzeżdżon, Joanna
    Jacewicz, Dagmara
    Powiązania:
    https://bibliotekanauki.pl/articles/1409708.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki kompleksowe
    radiofarmaceutyki
    obrazowanie medyczne
    właściwości hipoglikemiczne
    complex compounds
    radiopharmaceuticals
    medical imaging
    hypoglycemic properties
    Opis:
    In this review, the most important complex compounds of ruthenium, gold, vanadium, chromium, bismuth, technetium were selected, and then their most important applications were described in medicine. Ruthenium has been identified as a metal with potential medical use, useful in cancer chemotherapy. The possibility of using its chemical behavior by developing complexes activated for cytotoxic activity through a mechanism of reduction in tumor tissue was discovered. Among the new anti-cancer drugs based on complex compounds, gold compounds have gained a lot of interest. This is due to their strong inhibitory effect on the growth of cancer cells and the observation that many compounds inhibit the enzyme thioredoxin reductase. This enzyme is important for the proliferation of cancerous tissues, and its inhibition is associated with the release of anti-mitochondrial effects. Clinical tests have shown that vanadium compounds can be used as anti-diabetic drugs with low toxicity. However, the therapeutic concentration range is very narrow, just a few micromoles of the compound are enough to cause apoptosis, necrosis and inflammation of healthy cells. Chromium improves the glucose system in people with hypoglycemia or hyperglycemia. Vanadium compounds mainly used to create potential drugs are inorganic compounds such as vanadates(V), vanadyl cation(IV), vanadium oxide(V) and a number of compounds containing organic ligands. Among the metal complexes, chromium(III) picolinate has successfully become a nutrient used to prevent high blood sugar levels. One of the most commonly used bismuth(III) compounds is bismuth subsalicylate. It is one of the few bismuth compounds regularly used to treat various gastrointestinal complaints, including duodenal ulcers. 99mTc injected into the body, depending on its chemical form and molecular structure, concentrates in the examined organ and emits a quantum that allows imaging of the organ through flat scintigraphic or emission processes. The role of complex compounds in medical imaging is largely based on the creation of radiopharmaceuticals for early detection of diseases and cancer radiotherapy. Radiopharmaceuticals are radionuclide-containing drugs and are routinely used in nuclear medicine to diagnose or treat a variety of diseases.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 11-12; 823-851
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Związki kompleksowe chromu(III), wanadu(IV) i kobaltu(II) jako nowe prekatalizatory polimeryzacji olefin
    Chromium(III), vanadium(IV) and cobalt(II) complex compounds as new olefin polymerization precatalysts
    Autorzy:
    Drzeżdżon, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/171572.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    chrom
    wanad
    kobalt
    związki kompleksowe
    prekatalizatory
    polimeryzacja
    chromium
    vanadium
    cobalt
    complex compounds
    precatalysts
    polymerization
    Opis:
    The olefin polymerization catalysts constitute a large group of various compounds. Metallocene complexes are the largest part of this group. However, due to the instability at industrial plastics temperatures and the decomposition of complexes after MAO (or MMAO) activation, they have been partly replaced by non-metallocene compounds. This article concerns the studies on new non- metallocene precatalysts for the olefin polymerization and oligomerization. The report focuses on the structure and the catalytic activities of the complexes of chromium(III), vanadium(IV) and cobalt(II) with the following ligands: dipicolinate, 2-pyridinecarboxylate, oxalate, oxydiacetate, iminodiacetate, 2,2’- bipyridine, 4,4’-dimethoxy-2,2’-bipyridine, 1,10-phenantroline. These complex compounds are highly active precatalysts for olefin polymerization and oligomerization. The complexes: [Cr(dipic)2][Cr(bipy)(dipic)H20]-2H20 and [Cr(dipic) 2]Hdmbipy2.5H20 deserve special attention because they are new type of the precatalysts i.e. organic salt type complexes composed both of organic cations and anions. These compounds are not only interesting because of their structure but also because of their high catalytic activity.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 5-6; 423-437
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowanie polikarboksylanowych związków kompleksowych w tworzeniu sieci metaloorganicznych typu MOF
    Application of polycarboxylate comlexes in the formation of metal-organic frameworks
    Autorzy:
    Zych, Dominika
    Drzeżdżon, Joanna
    Jacewicz, Dagmara
    Chmurzyński, Lech
    Powiązania:
    https://bibliotekanauki.pl/articles/171746.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki metaloorganiczne typu MOF
    trójwymiarowa struktura
    fizykochemiczne właściwości związków typu MOF
    zastosowanie związków typu MOF
    Metal–Organic Frameworks
    MOF
    three-dimensional framework structure
    physicochemical properties of MOF
    applications MOFs
    Opis:
    The first research on Coordination Polymers began at the beginning of the 20th century. Wider understanding of their structure has enabled the development of crystallography. Since then compounds, which belong to this group, have been the subject of broad-spectrum scientific research. A particular class of these compounds, known relatively recently, are Metal–Organic Frameworks (MOF). The MOF structure is based on negatively charged organic linkers, e.g. polycarboxylic anions connected to various metal cations or metal clusters. MOFs are mainly built up from metal cations: transition, alkaline earth, main groups of the periodic table, as well as rare earth metals. Moreover, organic ligands used in the construction of MOF materials should contain electron donors. A characteristic bond, that allows the formation of hybrids, through the interactions of nodes and bridges is the coordination bond. It allows to synthesize a three-dimensional framework structure. Modern synthesis leads to the generation of porous materials with a very large surface area of pores and unique properties. Considering their synthesis, crystalline structures and physicochemical properties of MOF, as well as broad MOFs applications including gas storage, separation, catalysts, luminescence, magnetism and others, it is reasonable to state that MOFs can be used in many areas, not only in science, but also in environmental protection and in industry, for example, energy industry, chemical and biochemical industry.
    Źródło:
    Wiadomości Chemiczne; 2019, 73, 5-6; 401-423
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Związki kompleksowe na bazie Gd(III), W(IV), Mn(II), Eu(III) i 99mTc wykorzystywane w diagnostyce medycznej
    Complex compounds based on Gd(III), W(IV), Mn(II), Eu(III) and 99mTc used in medical diagnostics
    Autorzy:
    Pobłocki, Kacper
    Drzeżdżon, Joanna
    Jacewicz, Dagmara Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/2200431.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    obrazowanie medyczne
    związki kompleksowe
    magnetyczny rezonans jądrowy
    tomografia emisyjna pojedynczego fotonu
    rentgenografia
    obrazowanie optyczne
    medical imaging
    complex compounds
    magnetic resonance imaging
    single-photon emission computed tomography
    rentgenography
    optical imaging
    Opis:
    Recently, hospitals have undergone major changes. Minimally invasive surgery is becoming more common, and numerous innovations are emerging, such as interventional radiology (IVR) and hybrid surgery. In order to keep pace with changes in this extremely dynamic field, scientist keep working on the development of imaging technology and the improvement of image display devices and new compounds acting as contrast agent (CA). In medicine, metals are used for diagnostic and therapeutic purposes. Inorganic elements are increasingly used as contrast agents in medical imaging due to their unique physicochemical properties. In this review, we would like to focus on the latest literature reports that contain information on Gd(III), W(IV), Mn(II), Eu(III) and 99mTc used in medical diagnostics.
    Źródło:
    Wiadomości Chemiczne; 2022, 76, 9-10; 803--823
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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