- Tytuł:
- A novel cis-peptide bond motif inducing β-turn type VI. The synthesis of enkephalin analogues modified with 4-aminopyroglutamic acid.
- Autorzy:
-
Kaczmarek, Krzysztof
Kaleta, Maciej
Chung, Nga
Schiller, Peter
Zabrocki, Janusz - Powiązania:
- https://bibliotekanauki.pl/articles/1044069.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
constrained enkephalin analogues
4-aminopyroglutamic acid
cis-peptide bond
β-turn mimetic - Opis:
- A new pathway leading to a mixture of four isomers of 4-aminopyroglutamic acid is described. Michael type addition of Z-ΔAla-OMe to enolates prepared from acylaminomalonates, followed by hydrolysis and decarboxylation give protected 4-aminopyroglutamic acid with the 4-aminopyroglutamic acid with the cis:trans ratio approximately 3:2. This mixture was incorporated into Leu-enkephalin (position 2-3). After separation of peptides it appeared that all analogues were essentially inactive in guinea pig ileum and mouse vas deferens bioassays.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 4; 1159-1163
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł