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    Wyświetlanie 1-2 z 2
    Tytuł:
    Psychological factors and genetic characteristics of rural cannabis users
    Autorzy:
    Lachowicz, M.
    Chmielowiec, J.
    Chmielowiec, K.
    Suchanecka, A.
    Michałowska-Sawczyn, M.
    Mierzecki, A.
    Mroczek, B.
    Grzywacz, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085700.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    addiction
    polymorphism
    personality traits
    cannabis
    Opis:
    Introduction. Marijuana is one of the most widely used psychoactive substance. There is evidence of genetic predisposition for addiction. Objective. The aim of the study is to evaluate personality traits measured by the NEO Five-Factor Inventory and State-Trait Anxiety Inventory, combined with analysis of Tag1B rs1079597 and Tag1D rs1800498 located in the DRD2 gene. Materials and method. The study group consisted of 214 rural cannabinoid users and 301 controls. The same psychometric test and real-time PCR genotyping were performed in both studied groups. Results. The values of Anxiety state, Anxiety trait, NEO FFI: Neuroticism and Openness in the rural cannabis using group were significantly higher than in the control group. On the other hand, lower values were observed among rural people using cannabis compared to the control group for NEO FFI: Extraversion, Agreeability and Conscientiousness. In the Anxiety trait subscale, a 2% association with the polymorphism DRD2 Tag1B rs1079597 was detected in subjects using cannabis. However, for the DRD2 Tag1D rs1800498, there was no effect on the differences in personality traits between rural cannabis users and the control group. Conclusions. The study shows differences in personality traits between the cannabis using group and controls. Interaction between genetic factors and personality traits was also detected. The association showing the combination of psychological characteristics and genetic variants can bring us closer to the overall picture of the issue of marijuana addiction.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 260-268
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Significant association of DRD2 and ANKK1 genes with rural heroin dependence and relapse in men
    Autorzy:
    Lachowicz, M.
    Chmielowiec, J.
    Chmielowiec, K.
    Suchanecka, A.
    Masiak, J.
    Michałowska-Sawczyn, M.
    Mroczek, B.
    Mierzecki, A.
    Ciechanowicz, I.
    Gezywacz, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085710.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Addiction
    heroin
    dopamine
    haplotypes
    Opis:
    Introduction. Substance abuse significantly influences human health and may induce problems with social functioning worldwide. Numerous genetic and environmental risk factors, as well as their interactions, accelerate the development of drug addiction. Etiologically, the dopaminergic mesocorticolimbic reward pathways are related to psychoactive substance addiction, and the reward properties of heroin are connected with changes in the mesolimbic dopaminergic system. Objective. The aim of this study is a haplotypic analysis of subjects addicted to polysubstance. However, with the knowledge that this is not a homogenous subgroup, it was decided to separate and analyze homogenous subgroups of subjects in order to find specific haplotypic variants among them. The subjects in the subgroups were addicted to heroin, and subjects with more than two relapses in the past two years. Materials and method. The study group comprised of 301 polysubstance addicted rural male subjects. From this group, 2 homogenous subgroups of subjects were isolated and additionally analyzed: (1) a group of heroin addicted subjects (n=61), and (2) a group of heroin-addicted subjects with at least two relapses in the last two years (n=21). The group consisting of all polysubstance addicted rural subjects and both homogenous subgroups were analyzed against a control group of non-addicted subjects (n=300), matching gender and age. Five polymorphisms in the DRD2/ANKK1 region were analyzed: rs1076560, rs1800498, rs1079597, rs6276 in the DRD2 gene, and rs1800497 in the ANKK1 gene. Results. A statistically significant haplotype association was found in analysis of the heroin addicted subjects, compared to controls, and two possible trends – when comparing the whole group of addicted subjects to controls, and in relapse subgroups, compared to the controls. Conclusion. The results obtained showed that haplotypes indicate a part of the biological component of addiction.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 269-273
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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