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Wyszukujesz frazę "Chen, Bin" wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Research on the risk classification of cruise ship fires based on an attention-BP neural network
Autorzy:
Xiong, Zhenghua
Xiang, Bo
Chen, Ye
Chen, Bin
Powiązania:
https://bibliotekanauki.pl/articles/32912853.pdf
Data publikacji:
2022
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
cruise fire
simulation modeling
ensemble learning
BP neural network
Opis:
Due to the relatively closed environment, complex internal structure, and difficult evacuation of personnel, it is more difficult to prevent ship fires than land fires. In this paper, taking the large cruise ship as the research object, the physical model of a cruise cabin fire is established through PyroSim software, and the safety indexes such as smoke temperature, CO concentration, and visibility are numerically simulated. An Attention-BP neural network model is designed for realizing the intelligent identification of a cabin fire and dividing the risk level, which integrates the diagnosis results of multiple neural network models through the self-Attention mechanism and adaptively distributes the weight of each BP neural network model. The proposed model can provide decision-making reference for subsequent fire-fighting measures and personnel evacuation. Experimental results show that the proposed Attention-BP neural network model can effectively realize the early warning of the fire risk level. Compared with other machine learning algorithms, it has the highest stability and accuracy and reduces the uncertainty of early cabin fire warning.
Źródło:
Polish Maritime Research; 2022, 3; 61-68
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells
Autorzy:
Dai, Shuangshuang
Zheng, Yingru
Chen, Bin
Gao, Min
Zhang, Yan
Zhang, Li
Gong, Wei
He, Fengtain
Powiązania:
https://bibliotekanauki.pl/articles/1040492.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
APRIL
Gln187 mutant of sAPRIL
anti-tumor activity
Opis:
Soluble APRIL (sAPRIL), the active form of a proliferation-inducing ligand (APRIL), is implicated in the proliferation of tumor cells. Suppressing APRIL function has been considered as a potential strategy for the therapy of APRIL-associated tumors. In the present study, we generated human sAPRIL and its two mutants, Gln187-D-sAPRIL (Gln187 deleted) and Gly187-sAPRIL (Gln187 replaced by Gly). In vitro experiments showed that the two mutants had similar specific binding capacity to lung carcinoma A549 cells compared to the wild-type sAPRIL, and both, especially Gly187-sAPRIL, exhibited significant antagonistic effect on sAPRIL-induced tumor cell proliferation in a dose-dependent manner, which might be predominantly mediated by blocking sAPRIL-induced MEK and ERK phosphorylation but not p38MAPK or JNK signaling. In vivo experiments with nude mice bearing A549 cell-derived xenograft tumor showed that only the Gly187-sAPRIL mutant could significantly suppress the tumor growth. These results suggest that Gln187 may be a crucial amino acid in APRIL-mediated tumor cell proliferation via the MEK-ERK signaling pathway and that the sAPRIL mutants may serve as novel potential antagonists of APRIL for the therapy of APRIL-associated cancers.
Źródło:
Acta Biochimica Polonica; 2009, 56, 4; 703-710
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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