- Tytuł:
-
Analityka antybiotyków β-laktamowych w układzie in silico, in vitro oraz in vivo
Analytics of beta-lactam antibiotics in silico, in vitro and in vivo - Autorzy:
-
Janiszewska, Daria
Szultka-Młyńska, Małgorzata
Buszewski, Bogusław - Powiązania:
- https://bibliotekanauki.pl/articles/2086736.pdf
- Data publikacji:
- 2022
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
związki biologicznie aktywne
techniki chromatograficzne
elektrochemia
in vitro
in vivo
spektrometria mas
metabolizm
monitorowanie leków
biologically active compounds
chromatographic techniques
electrochemistry
mass spectrometry
metabolism
drug monitoring - Opis:
- Drug analysis necessitates introducing selective methods of detection and enriching the substances present in biomaterial at low concentration levels (trace analysis). Moreover, there is a continuous demand for increase in the quality of drugs that are being developed, which in turn enforces the development of analytical techniques of increasing sensitivity and accuracy with the applicationof combined separation techniques. Thus the premise of this review is to comparethe in vitro metabolic pathways of antibiotic drugs in model conditions such as in the presence of different microsomal fraction enzymes and with the applicationof electrochemical stimulation of metabolic transformations, as well as to the collected data with the results of in vivo experiments.
- Źródło:
-
Wiadomości Chemiczne; 2022, 76, 3-4; 109--127
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł