- Tytuł:
- Molecular profile of sensitization in subjects with short occupational exposure to latex
- Autorzy:
-
Lamberti, Monica
Buonanno, Rosaria
Ritonnaro, Chiara
Giovane, Giancarlo
Crispino, Vincenzo
Feola, Antonia
Medici, Nicola
Sannolo, Nicola
Di Carlo, Angelina
Di Domenico, Marina - Powiązania:
- https://bibliotekanauki.pl/articles/2177165.pdf
- Data publikacji:
- 2015-07-17
- Wydawca:
- Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
- Tematy:
-
occupational exposure
ImmunoCAP
natural rubber latex
skin prick test
contact dermatitis
gloves - Opis:
- Objectives We examined the prevalence of latex allergy in subjects with occupational exposure to latex allergens for less than 5 years, determining the disease spectrum in symptomatic workers. We identified the most frequent molecular allergens by Immuno- CAP (ICAP), correlating the findings with skin prick test (SPT) results. Material and Methods Seven hundred twenty-three healthcare students using latex gloves on a regular basis were invited to participate in a baseline questionnaire screening. An ICAP serum test was performed only when a possible latex allergy was indicated by the questionnaire. Results The total number of participants responding to the baseline survey was 619. Glove-related symptoms were indicated by 4% (N = 25) of the students. The most common symptom was contact dermatitis (N = 18, 72%). In 12 subjects, ICAP revealed a real sensitization to latex, with a recombinant latex allergen profile showing a high frequency for rHev b 6.01 specific immunoglobulin E (sIgE) (N = 9, 67%). In these individuals, skin symptoms were more prevalent than other types (88%). Conclusions The combined positivity for rHev b 6.01, rHev 8 and rHev b 5 determined by ICAP identified 92% of latex-allergic subjects with short-term exposure to latex.
- Źródło:
-
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 5; 841-848
1232-1087
1896-494X - Pojawia się w:
- International Journal of Occupational Medicine and Environmental Health
- Dostawca treści:
- Biblioteka Nauki
Artykuł