- Tytuł:
- Direct transfer of IL-12 gene into growing Renca tumors.
- Autorzy:
-
Budryk, Magdalena
Wilczyńska, Urszula
Szary, Jarosław
Szala, Stanisław - Powiązania:
- https://bibliotekanauki.pl/articles/1044365.pdf
- Data publikacji:
- 2000
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
IL-12 gene
tumor gene therapy
naked DNA - Opis:
- We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/ DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.
- Źródło:
-
Acta Biochimica Polonica; 2000, 47, 2; 385-391
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł