- Tytuł:
- Preliminary evaluation of mutagenic activity of two amino derivatives of cyclopenta[c]phenanthrene
- Autorzy:
-
Łuczyński, M. K.
Góra, M.
Mielżyńska, D.
Brzuzan, P.
Tejs, S.
Pirogowicz, P.
Luczynski, M. - Powiązania:
- https://bibliotekanauki.pl/articles/363278.pdf
- Data publikacji:
- 2007
- Wydawca:
- Uniwersytet Warmińsko-Mazurski w Olsztynie
- Tematy:
-
test Amesa
fenantren
mutacje DNA
WWA
Ames test
phenanthrene
DNA mutations
PAHs - Opis:
- The mutagenicity of two, newly synthesized amino-derivatives of cyclopenta[c]phenanthrene (CP[c]Ph) was investigated in the Ames test using TA98 and TA100 histidine dependent Salmonella typhimurium strains. Neither of the examined compounds showed mutagenic activity without metabolic activation. The incorporation of an activation system caused high mutagenicity of CP[c]Ph derivatives in both S. typhimurium strains. The results are compared with the previous data on the mutagenic activity of unsubstituted CP[c]Ph and possible mechanisms of activation are discussed.
- Źródło:
-
Environmental Biotechnology; 2007, 3, 1; 15-19
1734-4964 - Pojawia się w:
- Environmental Biotechnology
- Dostawca treści:
- Biblioteka Nauki
Artykuł