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    Wyświetlanie 1-2 z 2
    Tytuł:
    Seeking genetic determinants of selected metabolic disorders in women aged 45–60
    Autorzy:
    Szkup, M.
    Brodowski, J.
    Jurczak, A.
    Stanisławska, M.
    Grochans, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085996.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Genes
    Metabolic Syndrome X
    PPAR gamma
    Opis:
    Introduction and objective. The biochemical and anthropometric consequences of metabolic disorders exert an enormous effect on the functioning of people worldwide. The aim of this study is to assess relationships between biochemical and anthropometric parameters associated with metabolic syndrome, and the presence of the PPAR-γ rs1801282, the FTO rs9939609, and the MC4R rs17782313 polymorphisms in women aged 45–60. Materials and method. The study included 425 women, aged 45–59 years, from the general population of the West Pomeranian Province in north-west Poland. The research procedure involved a structured interview, anthropometric and blood pressure measurements, biochemical analysis of serum, and genetic analysis. Results. The carriers of the A/A genotype of the FTO polymorphism had higher LDL levels than their counterparts with the T/T genotype (p=0.01). The carriers of the T/T genotype of the MC4R polymorphism had lower non-HDL levels than those with the C/C and C/T genotypes (p=0.019). Weight was related to the C/C and the C/G + G/G genotypes of the PPAR-γ gene polymorphism (p=0.046). The model of inheritance for the MC4R polymorphism had a significant effect on TG (p=0.039) and non-HDL (p=0.05) levels. Conclusions. The genotypes analyzed in the study had only a slight direct effect on the biochemical and anthropometric abnormalities typical of metabolic disorders. Nonetheless, the risk alleles (A allele of the FTO rs9939609 and the C allele of the MC4R rs17782313) were found to be related to lipid metabolism disorders in 45–60-year-old women.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 407-412
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of menopausal hormone therapy on the levels of magnesium, zinc, lead and cadmium in post-menopausal women
    Autorzy:
    Jurczak, A.
    Brodowski, J.
    Grochans, E.
    Karakiewicz, B.
    Szkup-Jablonska, M.
    Wieder-Huszla, S.
    Mroczek, B.
    Wloszczak-Szubzda, A.
    Grzywacz, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/50553.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Introduction and objective: The level of trace elements is extremely important for the maintenance of normal functioning of the human body. The risk of disturbance of their balance increases especially dynamically during the period of menopause. The objective of the study was the effect of MHT on the levels of bioelements (Mg and Zn) in blood plasma, and toxic metals (Pb and Cd) in the whole blood in postmenopausal women. Materials and methods: The study covered 323 women at postmenopausal age from the population of the West Pomeranian Region, in whom the levels of Mg, Zn, Pb and Cd were determined. The women were divided into two groups: study and control. The study group were 152 women who used menopausal hormone therapy (MHT). The control group were 171 women who did not use MHT, and had had their final menstrual period at least one year prior to inclusion in the study. The mean age of the women examined was 56±5. Results: Significantly higher levels of the bioelements Mg, Zn were observed in women who used MHT, compared to the control group (p<0.05). The concentration of Pb in whole blood was significantly lower in the study than the control group: 16.09±7.33 μg/l and 20.18±9.01 μg/l, respectively. An elevated level of Cd in whole blood was found in both groups of women: 0.9±1.03 μg/l and 0.8±1.1 μg/l, respectively. It was noted that women who used MHT more frequently declared the presence of climacteric symptoms (p<0.05). Conclusions: 1) Higher levels of Mg and Zn were found in blood plasma of women who used MHT. 2) The mean concentration of Cd in the blood of women in both groups was similar. 3) In women who use MHT the level of Pb in whole blood was lower, compared to the rest of the women.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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