- Tytuł:
- An Application of Optimal Control Theory to the Design of Theoretical Schedules of Anticancer Drugs
- Autorzy:
-
Boldrini, J. L.
Costa, I. S. - Powiązania:
- https://bibliotekanauki.pl/articles/908297.pdf
- Data publikacji:
- 1999
- Wydawca:
- Uniwersytet Zielonogórski. Oficyna Wydawnicza
- Tematy:
-
chemioterapia
odporność na działanie leków
sterowanie optymalne
chemotherapeutic treatments
drug resistance
optimal control - Opis:
- A system of differential equations for the control of tumor growth cellsin a cycle non-specific chemotherapy is analyzed. Spontaneously acquired drug resistance is taken into account by means of a mutation rate non-decreasingly dependent on time and the drug kill rate is supposed to depend on the growth rate of sensitive cells. For general tumor growth and drug kill rates the optimal treatment consists in maximizing the allowable drug concentration throughout.
- Źródło:
-
International Journal of Applied Mathematics and Computer Science; 1999, 9, 2; 387-399
1641-876X
2083-8492 - Pojawia się w:
- International Journal of Applied Mathematics and Computer Science
- Dostawca treści:
- Biblioteka Nauki
Artykuł