- Tytuł:
- Mechanism of action of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide on homoterm animals and humans
- Autorzy:
-
Antonenko, A.M.
Blagaia, A.V.
Omelchuk, S.T.
Korshun, M.M.
Vavrinevych, H.P.
Milohov, D.S.
Pelo, I.M.
Bojar, I. - Powiązania:
- https://bibliotekanauki.pl/articles/3635.pdf
- Data publikacji:
- 2015
- Wydawca:
- Instytut Medycyny Wsi
- Tematy:
-
4-hydroxyphenylpyruvatedioxygenase
herbicide
homotherm animal
man
tyrosinemia
tyrosine aminotransferase
target organ
corneal capacity
liver
thyroid gland - Opis:
- It was found that the main mechanisms of action of 4-hydroxyphenylpyruvatedioxygenase inhibitors are the development of tyrosinemia and alternations in thyroid hormone level as a result of hepatic enzyme induction. The main target organs of its action are the eyes, liver and thyroid gland. It was proved that the most adequate model for extrapolation of the effects of tyrosinemia on humans are mice, because their tyrosine aminotransferase activity level is similar to that in humans.
- Źródło:
-
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395 - Pojawia się w:
- Journal of Pre-Clinical and Clinical Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł