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    Wyświetlanie 1-8 z 8
    Tytuł:
    Infliximab MRI relaxation time in solution
    Autorzy:
    Bober, Zuzanna
    Bar, Piotr
    Pasternak, Grzegorz
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454757.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    magnetic resonance imaging relaxation time
    Opis:
    Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 22-25
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Magnetic Resonance Elastography – noninvasive method to assess liver disease
    Autorzy:
    Ożóg, Łukasz
    Aebisher, David
    Bober, Zuzanna
    Bartusik-Aebisher, Dorota
    Guz, Wiesław
    Cholewa, Marian
    Powiązania:
    https://bibliotekanauki.pl/articles/454714.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    fibrosis
    liver stiffness
    MRE
    magnetic resonance imaging
    Opis:
    Currently, liver disease is widespread and the awareness of these diseases is low. Early symptoms of liver disease do not necessarily indicate problems with this organ and patients are usually informed of their problems when the stage of the disease is already advanced. Invasive biopsies are the clinical diagnostic method most commonly used in the evaluation of liver disease. A biopsy is associated with a high risk of false results and additional complications. Finding new non-invasive imaging methods has led to the discovery of a new method called Magnetic Resonance Elastography (MRE). This technique allows one to evaluate the mechanical properties of tissues and to distinguish between pathological states. Testing using this technique can be performed on a conventional magnetic resonance system by using few additional components and properly prepared software. Studies have shown that there is a strong correlation between MRE-measured liver stiffness and the degree of fibrosis. MRE is also useful in characterizing liver tumors. Studies show that this technique is highly credible in both health volunteers and patients with liver fibrosis. MRE has tremendous diagnostic potential. The described technique is not currently widely used and has the 127-132potential to serve as a safe and accurate alternative in clinical diagnostics in the future.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 127-132
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    19F MRI As a tool for imaging drug delivery to tissue and individual cells
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Ożóg, Łukasz
    Tabarkiewicz, Jacek
    Tutka, Piotr
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454941.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug delivery
    drug tracking
    fluorine
    magnetic resonance imaging
    Opis:
    Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 99-109
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Tabarkiewicz, Jacek
    Guz, Wiesław
    Tutka, Piotr
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454783.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug delivery systems
    drug forms
    magnetic resonance imaging pharmaceuticals
    Opis:
    Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 110-119
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contrast-enhanced Magnetic Resonance Imaging of lung cell cultures
    Autorzy:
    Bober, Zuzanna
    Pogoda, Katarzyna
    Aebisher, David
    Tabarkiewcz, Jacek
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/895529.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    Lung cancer
    cell cultures
    magnetic resonance imaging
    contrast media
    Gadolinium
    Opis:
    Lung cancer is one of the most common types of cancer diagnosed, and the development of methods to image diseased lung tissue by MRI is of utmost importance. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) was used to noninvasively evaluate spin-spin relaxation time, T1, of lung cell cultures infused with various clinical gadolinium-based contrast media for imaging. In this study we used a clinical 1.5 Tesla scanner and the contrast agents: Omniscan, MultiHance, Gadovist and ProHance. A significant five-fold reduction of T1 relaxation time was obtained.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 251-258
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The usefulness of relaxation time using MRI measurements
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Truszkiewicz, Adrian
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454698.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Magnetic Resonance Imaging
    T1 relaxation
    field strength 1.5 Tesla
    Opis:
    Introduction. Magnetic Resonance Imaging methods are now frequently used for the analysis of the diseased tissue. These methods are based on the fact that the spin-lattice, T1 , and the spin-spin, T2 , relaxation times are different in diseased tissue as compared to that of normal tissue. Aim. Here we present measurements of spin-lattice relaxation time T1 on a Magnetic Resonance Imaging scaner with field strength 1.5 Tesla. Material and methods. Measurements of T1 relaxation time and analysis of literature. Results. We provide procedure for measurements of T1 relaxation time with field strength 1.5 Tesla and present a discussion of current applications.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 224-227
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Radio Frequency MRI coils
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Bober, Zuzanna
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454860.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    field strength 1.5 Tesla
    magnetic resonance imaging
    radio frequency coil
    Opis:
    Introduction. Magnetic Resonance Imaging (MRI) coils technology is a powerful improvement for clinical diagnostics. This includes opportunities for mathematical and physical research into coil design. Aim. Here we present the method applied to MRI coil array designs. Material and methods. Analysis of literature and self-research. Results. The coils that emit the radiofrequency pulses are designed similarly. As much as possible, they deliver the same strength of radiofrequency to all voxels within their imaging volume. Surface coils on the other hand are usually not embedded in cylindrical surfaces relatively close to the surface of the body. Conclusion. The presented here results relates to the art of magnetic resonance imaging (MRI) and RF coils design. It finds particular application of RF coils in conjunction with bore type MRI scanners.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 24-27
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro
    Autorzy:
    Pogoda, Katarzyna
    Pucka, Maria
    Tabarkiewicz, Jacek
    Bober, Zuzanna
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454731.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cell cultures
    lung cancer
    lycopene
    kidney cancer
    magnetic resonance imaging relaxation times
    Opis:
    Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 5-9
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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