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    Wyświetlanie 1-3 z 3
    Tytuł:
    Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy
    Autorzy:
    Guz, Wiesław
    Bober, Zuzanna
    Ożóg, Łukasz
    Truszkiewicz, Adrian
    Przypek, Aneta
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Urbanik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454826.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    spectroscopy
    MR
    SVS
    CSI
    Opis:
    Continuous scientific research and the increasing saturation of the medical market in Poland implements the possibilities of using advanced MR techniques including MRS in everyday practice. This method, which has so far been used primarily for research purposes, can bring measurable benefits to patients not only in terms of clarifying diagnosis and narrowing differential diagnosis, but also monitoring the course of various diseases and their treatment. Here we present the basic principles of performing and interpreting spectroscopic spectra and possible clinical applications and development prospects of MRS. The literature reviewed both Polish and foreign articles both historically and in the past 10 years. The paper presents methodological issues related to the proper performance of magnetic resonance spectroscopy (MRS) and spectral composition and the role of major metabolites, as well as current clinical applications and directions of MRS development.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 133-140
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Applications of cytisine extraction and detection in biological materials for clinical medicine
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Courtney, Ryan
    Sobczak, Andrzej
    Bober, Zuzanna
    Podgórski, Rafał
    Kołodziejczyk, Patrycjusz
    Tutka, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/895314.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    smoking cessation
    chromatography
    Biomedicine
    cytisine extraction
    biopharmacy
    Opis:
    Tobacco use is a leading cause of preventable mortality worldwide. New cost-effective smoking cessation treatments are needed especially in some low-to-middle income countries where smoking rates are rising, and current pharmacotherapy treatments remain cost-prohibitive. Since the 1960’s, cytisine has been used as an effective nicotine substitution agent to aid in smoking cessation albeit limited to a selected few Eastern/Central Europe and Central Asian countries. Cytisine is a biologically active alkaloid of plant origin and is known to be a ligand of nicotinic acetylcholinergic receptors (nAChRs). For several decades, the properties of cytisine have been investigated and reported in the biomedical and pharmaceutical literature. Due to the beneficial impact of cytisine on smoking cessation and its costly multistep synthesis, there is a growing interest in extraction from natural sources as well as in analytical identification and quantification for clinical medicine and forensic toxicology. In this paper, we present several current analytical approaches to cytisine extraction and identification from biological samples of plant and human origin. The development of extraction techniques will allow for the widespread use of the drug in experimental and clinical pharmacology, toxicology and forensic medicine.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 797-804
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ASL (Arterial Spin Labeling) – historical and current perfusion MR methods
    Autorzy:
    Guz, Wiesław
    Bober, Zuzanna
    Ożóg, Łukasz
    Truszkiewicz, Adrian
    Przypek, Aneta
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Urbanik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454978.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    perfusion
    MR
    ASL
    Opis:
    Despite continuous scientific and technological advances in MR imaging, MR perfusion methods have not yet been widely deployed for routine clinical diagnostics. This is especially true for ASL (arterial spin labelling) methods used to evaluate cerebral perfusion. This method does not require a contrast agent, as new discoveries about gadolinium accumulation in the cerebellum and brain nucleus appear to be a valuable asset and provide the opportunity to be more widely deployed in clinical practice. The aim of this paper is to present the historical determinants of the development of MR perfusion techniques, the disadvantages and advantages and possible clinical applications and prospects of ASL development. Both historical articles published on MR in the 1990s and current research between 2006-2016 have been reviewed. The authors present in the work the MR perfusion method focusing on issues related to arterial spin labeling (ASL). Historically CASL (continuous ASL) and PCSL (pulsed ASL) techniques have been described and the pseudocontinuous ASL (pseudocontinuous ASL) 3D technique presents its technical and methodological considerations, advantages and disadvantages over previous methods. The methods of test protocol optimization and accompanying artifacts, as well as possible clinical applications and development perspectives, have been described.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 145-150
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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