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Wyświetlanie 1-3 z 3
Tytuł:
Leftward Spatial Bias in Dialyzed Patients with End-Stage Renal Disease: A Sign of Right Hemispheric Attentional Activation or Impaired Left-Sided Disengagement?
Autorzy:
Mańkowska, Aleksandra
Heilman, Kenneth
Williamson, John
Biedunkiewicz, Bogdan
Dębska-Ślizień, Alicja
Harciarek, Michał
Powiązania:
https://bibliotekanauki.pl/articles/2124649.pdf
Data publikacji:
2022-02-02
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
dialysis
line bisection
attentional bias
attentional disengagement
global attention
focal attention
Opis:
In the horizontal line bisection task, patients with end-stage renal disease (ESRD) treated with dialysis typically have an increase in the normal leftward attentional bias. It is not clear, however, whether this increased bias is related to an increase of attention toward left hemispace or impaired disengagement from left-sided stimuli. Non-demented patients with ESRD who were being treated with dialysis and demographically matched healthy controls attempted to bisect series of horizontal lines composed of two segments of unequal length and width, with the longer segment placed to the right or left. To test for the presence of a global spatial attentional bias, participants attempted to find the middle of the whole line. To test for focal attentional engagement and attentional disengagement, participants were asked to bisect only the longer segment of these compound lines. For the global condition, both patients and healthy controls were biased toward the longer segment and more so to the left. In the focal condition, when the longer segment was on the right side, both groups deviated their bisections toward the shorter segment. However, when in the focal condition the longer segment was on the left healthy controls deviated their bisection significantly more rightwards than did the patients, whereas with the longer segment on the right, the patients and healthy controls did not differ in their bias. These results suggest that the previously recognized dysfunction of the right fronto-subcortical attentional network in dialyzed patients might account for the results of the current study.
Źródło:
Roczniki Psychologiczne; 2021, 24, 3-4; 261-277
1507-7888
Pojawia się w:
Roczniki Psychologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aliskiren reduces albuminuria after kidney transplantation
Autorzy:
Tylicki, Leszek
Debska-Slizien, Alicja
Lizakowski, Slawomir
Przybylska, Milena
Heleniak, Zbigniew
Renke, Marcin
Chamienia, Andrzej
Biedunkiewicz, Bogdan
Rutkowski, Przemyslaw
Małgorzewicz, Sylwia
Rutkowski, Boleslaw
Powiązania:
https://bibliotekanauki.pl/articles/1038634.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
albuminuria
aliskiren
kidney transplantation
renoprotection
Opis:
Background: The renoprotective effects of the direct renin inhibitor, aliskiren, in renal transplant recipients have been supposed, but not finally proven. We performed an exploratory double-blind, losartan controlled, cross-over study to evaluate the influence of aliskiren, direct renin inhibitor, on albuminuria and other surrogate markers of kidney injury in patients after renal transplantation. The safety of this therapy was also evaluated. Method: 16 of 18 patients (12 M, 4 F), 48.3 ± 9.0 years, 57.7 ± 9.1 months after kidney transplantation, with hypertension and stable serum creatinine 1.4 ± 0.08 mg/dl without proteinuria, completed the protocol. Each patient underwent two 8-week treatment periods (one with 150 mg of aliskiren, and one with 50 mg of losartan) in random order, allowing an 8-week placebo washout between them. Results: There were no differences in albuminuria, transforming growth factor β-1 and 15-F2t-isoprostanes urine excretion between aliskiren and losartan. Creatinine serum level, eGFR, 24 h systolic and 24 h diastolic blood pressure were stable through the study. There were no differences in haemoglobin and potassium serum concentration between studied drugs. Conclusion: Aliskiren decreases albuminuria in renal transplant recipients with clinically minimal side effects. The effect does not differ from that of losartan.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 221-226
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SARS-CoV-2 infection in vaccinated maintenance hemodialysis patients despite anti-spike seroconversion: a report of 3 breakthrough cases
Autorzy:
Biedunkiewicz, Bogdan
Tylicki, Leszek
Puchalska-Reglińska, Ewelina
Dąbrowska, Małgorzata
Ślizień, Waldemar
Kubanek, Alicja
Rąbalski, Łukasz
Kosiński, Maciej
Grzybek, Maciej
Renke, Marcin
Dębska-Ślizień, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/2203183.pdf
Data publikacji:
2022-03-01
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
SARS-CoV-2
breakthrough infection
hemodialysis
vaccination
Opis:
Chronically hemodialyzed (HD) patients are at a high risk of developing very severe forms of COVID-19 disease. In this article we describe three HD patients (all males, aged 70, 70 and 74 years) vaccinated intramuscularly with a two-dose mRNA BNT162b2 vaccine; BionTech/Pfizer Comirnaty, in whom subsequent breakthrough SARS-CoV-2 infections developed. All patients achieved post-vaccine seroconversion for anti-spike antibodies with IgG titers of 445, 227 and 92.5 AU/mL (cut-off, 13 AU/mL) case 1, 2 and 3 respectively. SARS-CoV-2 infection was diagnosed 44, 28 and 48 days after the second dose of BNT162b2 and confirmed with the polymerase-chain-reaction (PCR) test. Two asymptomatic patients underwent this test because of their direct contact with a person with confirmed COVID-19. The third patient reported only a non-significant drop in oxygen saturation, and was hospitalized (case 3). All these patients were characterized by a low post-vaccination neutralizing antibody titer and a high production of these antibodies after falling ill (795, 845 and 5770). Perhaps this production of antibodies is responsible for the mild course of the disease, and the likely reduction of mortality. These breakthrough cases in no way undermine the importance of the vaccinations, and on the contrary argue for their urgency.
Źródło:
European Journal of Translational and Clinical Medicine; 2022, 5, 1; 12-16
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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