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    Wyświetlanie 1-6 z 6
    Tytuł:
    Neoadjuvant therapy in breast cancer – objectives and tasks
    Autorzy:
    Ostańska, Elżbieta
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454710.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    neoadjuvant therapy (NCT)
    breast cancer (BC)
    triple negative breast cancer (TNBC)
    Opis:
    Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 153-156
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging methods of early detection and screening for breast cancer. A review
    Autorzy:
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454888.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast cancer
    breast MRI
    early detection
    screening
    Opis:
    Introduction. Breast cancer is the most frequent neoplasm among women. That is the reason why scientists all over the world are attempting to improve early detection methods of this particular malignancy. Aim. The most common and most widely used examination methods for screening for and detecting breast cancer is presented herein. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases. Results. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. Conclusion. The role of a physician is to select the most suitable one for each patient in order to obtain the best result. No matter the method however, between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 142-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Epidemiology of breast cancer in Podkapackie voivodship
    Autorzy:
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Ostańska, Elżbieta
    Przyczyna, Piotr
    Osuchowski, Michał
    Aebisher, David
    Galiniak, Sabina
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454657.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast cancer
    statistics
    epidemiology
    podkarpackie voivodship
    Opis:
    Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 242-245
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Trastuzumab Efficacy Quantified by Fluorine-19 Magnetic Resonance Imaging
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Mrs Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895489.pdf
    Data publikacji:
    2020-06-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    trastuzumab
    magnetic resonance imaging
    breast cancer cells
    three-dimensional cell culture
    Trastuzumab conjugates
    Opis:
    The purpose of this study was to conjugate Trastuzumab with fluorine-bearing PAMAM dendrimer to compare activities in three-dimensional (3D) cultured breast cancer cells with parent Trastuzumab. An in vitro study was performed to determine cellular responses to fluorinated Trastuzumab conjugates by Magnetic Resonance Imaging (MRI). Breast cancer cells were cultured in 3D geometry. Proton (1H) MRI and Fluorine-19 (19F) MRI were used for visualization of cellular locations within a Hollow Fiber Bioreactor (HFBR) device and to monitor the cellular response to treatment. The results of this study confirm that cell growth is significantly decreased following treatment with Trastuzumab conjugates. The use of fluorinated Trastuzumab conjugates decreases breast cancer cell growth in 3D cultures and allows for tracking of drug delivery to cancer cells via 19F.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 495-503
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The use of imaging tests to obtain optimal margins in breast surgery
    Autorzy:
    Ostańska, Elżbieta
    Bartusik-Aebisher, Dorota
    Gustalik, Joanna
    Aebisher, David
    Galiniak, Sabina
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1597322.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast conserving surgery
    ductal carcinoma in situ
    extensive itraductal component invasive breast cancer
    lobular carcinoma in situ
    Opis:
    Introduction. The proper negative margins (R0) breadth in the breast - conserving surgery for invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) is very important. The presence positive surgical margins (R1) is associated with the necessity of reoperation. It delays the adjuvant therapy and psychologically burdens the patient. The re-operation increases the costs of treatment. The introduction of mammography (MMG) increased detection of DCIS by 20%. With the increase in malignancy, cancer detection decreases in MMG, inversely in MRI groving. Effective preoperative and intraoperative diagnosis aims to reduce the number of R1 resections. Aim. The size of the tumor next to its biology, determines the clinical course of the tumor. The accurate analysis of imaging tests is important. Material and methods. This analysis was performed using a systematic literature search. Results. Adequate surgical margins in breast cancer surgery for breast cancer have been reviewed. It is important to know if the cancer is multifocal and what the extent of the tumor is. Conclusion. The adequacy of margins is important for adjusting the volume of excision. It is avoiding unnecessary resection of healthy breast tissue. It is essential for a good cosmetic result and the local recurrence rate. The combination of breast MRI with conventional breast imaging resulted in the lover rate of the R1 resectios and the lower rate of the re-operation.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 246-249
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of MR relaxation times following trastuzumab treatment of breast cancer cells in a 3D bioreactor
    Autorzy:
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Czmil, Anna
    Mazur, Damian
    Powiązania:
    https://bibliotekanauki.pl/articles/895234.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    magnetic resonance imaging (MRI)
    breast cancer cell cultures
    hollow-fiber bioreactor (HFBR)
    relaxation time maps
    Opis:
    The three dimensional tumor environment can be mimicked with the use of cells cultured within a hollow-fiber bioreactor (HFBR). In this work, magnetic resonance imaging (MRI) was used to monitor changes in relaxation time in breast cancer cells following treatment with Trastuzumab in a HFBR system. Breast cancer cells were inoculated into the HFBR system and cultured over a period of 4 weeks. Relaxation time maps were generated according to MRI techniques in three dimensional (3D) cultures of MCF7/Her2 breast cancer and MCF7/Neo4 control cells. MRI measurements showed a variation in values of spin-lattice (T1) and spin-spin (T2) relaxation times related to cell density. Differences in both values (T1 and T2) were noted between untreated cells and cells treated with trastuzumab in the HFBR device. Additionally, 1H MRI was able to provide information about drug penetration in breast cancer cell culture organized in 3D. In conclusion, MRI in vitro can provide direct, noninvasive visualization of cell density in 3D geometry and cell viability as a function of drug uptake. Both T1 and T2 values were higher for lower cell density and accordingly both values, T1 and T2, were lower for higher cell density.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 35-41
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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