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Wyszukujesz frazę "HSP" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
Increased levels of antibodies against heat shock proteins in stroke patients
Autorzy:
Banecka-Majkutewicz, Zyta
Grabowski, Michał
Kadziński, Leszek
Papkov, Aliaksei
Węgrzyn, Alicja
Banecki, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1039307.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
HSP
Heat Shock Proteins
Stroke
DnaK
DnaJ
GroEL
Hsp70
ELISA
Opis:
Ischemic stroke is the second leading cause of death worldwide. One of the main risk factors of the ischemic stroke is atherosclerosis which is a chronic inflammatory and immune-mediated disease. Bacterial infections generate specific human antibodies against various antigens, including Hsps. It has been demonstrated that Hsps are selectively overexpressed in the atherosclerotic lesions. The amino acid sequence homology between human and bacterial Hsps may lead to an autoimmune response by immunological cross-reaction. Such immune response against Hsps overexpressed in the blood vessels under stressful conditions may contribute to inflammatory processes and subsequent development of atherosclerosis. In this study we determined the antibody levels against bacterial and human Hsp by ELISA in blood plasma obtained from stroke patients. Using ANOVA we analyzed levels of Hsp-antibodies in control and patient groups and correlate them with several stroke risk factors. The group of stroke patients had elevated levels of anti-Hsp antibodies compared to the control group. We also discovered an antibody level increase in patients that previously underwent another stroke. Our data provide evidence that autoimmunity could underlie formation of atherosclerosis plaque leading to stroke.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 379-383
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of heat-shock proteins and cobalamine in maintaining methionine synthase activity
Autorzy:
Grabowski, Michał
Banasiuk, Rafał
Węgrzyn, Alicja
Kędzierska, Barbara
Lica, Jan
Banecka-Majkutewicz, Zyta
Banecki, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1039633.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vitamin B12
HtpG
cobalamine
HSP
methionine syntase (MetH)
Hsp 70/100
Opis:
Atheromatous plaque is one of the most common cardiovascular-related diseases. Reports show a connection between its development and the levels of homocysteine. In pathological states high levels of homocysteine in the organism can be caused by the malfunction of the methionine synthase pathway. Bacterial methionine synthase (MetH) is a homologue of the human methionine syntase (MS). In this study we aimed to investigate the functional relations between MetH and its cofactor - cobalamine - under stress conditions. We have demonstrated that heat shock proteins (Hsp 70/100 system or HtpG) can protect MetH activity under stress conditions. Moreover, in the presence of cobalamine they can restore the activity of partially denatured methionine synthase.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 489-493
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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