- Tytuł:
- Orientation of lutein in a lipid bilayer - revisited
- Autorzy:
-
Pasenkiewicz-Gierula, Marta
Baczyński, Krzysztof
Murzyn, Krzysztof
Markiewicz, Michał - Powiązania:
- https://bibliotekanauki.pl/articles/1039792.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
molecular modeling
tilt angle
macular pigment - Opis:
- Lutein is present in the human retina and lens, where it plays a protective role. As lutein is associated with the lipid matrix of biomembranes, the role depends on its membrane location. Experimental studies predicted two orientations of lutein in a phosphatidylcholine (PC) bilayer: vertical and horizontal. Using a molecular dynamics simulation, we observed, in two different PC bilayers, both orientations of lutein, and in each bilayer, a single change from vertical to horizontal orientation or vice versa. Both orientations were stabilized by hydrogen bonding of lutein OH groups with mainly carbonyl but also phosphate oxygen atoms of PC.
- Źródło:
-
Acta Biochimica Polonica; 2012, 59, 1; 115-118
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł