Autor: Zych, M - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Porowate materiały nanokompozytowe modyfikowane cząstkami krzemionki
Porous nanocomposite materials modified with silica nanoparticles
Autorzy:: Stodolak-Zych, E.
Porąbka, A.
Błażewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/285322.pdf
Data publikacji:: 2012
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: nanokompozyty
bioaktywność
skafoldy
medycyna regeneracyjna
nanocomposites
bioactivity
scaffolds
regenerative medicine
Opis:: W pracy otrzymano nanokompozyty poli-L/DLlaktydu (PLDLA) z nanocząstkami krzemionki, różniące się zawartością wymiarami cząstek: 5-10 nm (Aldrich) i 15 nm (NanoAmor) oraz rozwinięciem powierzchni. Wpływ nanododatków na matrycę polimerową określono przy pomocy badań mikrostruktury (AFM) oraz badań technikami FTIR-ATR. Próbki modelowe w postaci folii 2D zostały poddane badaniom degradacji warunkach in vitro, których postęp badano przy zastosowaniu analizy termicznej (DSC/TG), spektroskopii w podczerwieni (FTIR). Rezultaty powyższych badań pozwoliły na wyselekcjonowanie nanonapełniacza, który zastosowano do otrzymania porowatych podłoży (3D). Skafoldy otrzymano metodą odmywania stosując jako porogen uwodnione sole fosforanowe. Na podstawie obserwacji mikrostruktury, pomiaru porowatości otwartej oraz badania mechanicznego gąbek wytypowano potencjalne podłoże dla komórek kostnych, wytworzone z najkorzystniejszym udziałem wagowym porogenu. Stwierdzono, że najlepsze właściwości mechaniczne porowatych nanokompozytowych materiałów otrzymuje się przy 50% udziale porogenu. Obecność nanocząstki ceramicznej wpływa na bioaktywność tworzywa (inkubacja w SBF).
The paper presents poli-L/DL-lactide (PLDLA) nanocomposites containing silica nanoparticles which differ in size: 5-10 nm (Aldrich) and 15 nm (NanoAmor) as well as in the specific surface area. The influence of nanofillers on polymer matrix was determined through studies on microstructure (AFM) and FTIR-ATR testing technique. Model samples in the form of 2D thin films underwent degradation in in vitro conditions. The process was registered using thermal analysis (DSC/TG) and infrared spectroscopy (FTIR). The results of these studies allowed the selection of a nanofiller which later was used to obtain porous 3D scaffolds. The scaffolds were produced with salt-leaching method using hydrated phosphate salts as a porogen. On the basis of microstructure observation measurement of open porosity and mechanical testing the potential scaffold for bone cells culture and regenerative medicine was chosen: the one with the most preferable weight fraction of porogen. It was found that the best porosity of characterized nanocomposite materials with 50 wt% of porogen. The presence of ceramic nanoparticles influenced the bioactivity of the material (incubation in SBF).
Źródło:: Engineering of Biomaterials; 2012, 15, 112; 12-19
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Carbon nanocomposite membrane with bioactive fillers
Autorzy:: Stodolak-Zych, E.
Szatkowski, P
Błażewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/285168.pdf
Data publikacji:: 2016
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: nanocomposites
membranes
bioactive fillers
Źródło:: Engineering of Biomaterials; 2016, 19, 138; 57
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Polylactide - carbon nanotubes nanocomposites as membranes for guided nerve regeneration (GNR)
Autorzy:: Stodolak-Zych, E.
Frączek-Szczypta, A.
Błażewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/285045.pdf
Data publikacji:: 2012
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: nanocomposites
membranes
nerve regeneration
Opis:: New generation of membrane materials can play role in regeneration process in living organism e.g. creation of optimal conditions for regeneration of bone tissue (GBR/GTR technique) or defected peripheral nerve (GNR technique). However, biodegradable polymeric materials which are now widely used in GNR technique (PLA, PCL, collagen) does not have satisfactory mechanical properties such as strength (RM) or Young's modulus (E) because it is difficult to control their porosity [1,2]. Materials suitable for nerve regeneration should exhibit electrical properties which stimulate the regeneration [3]. The main idea of the guided nerve regeneration is utilisation of a membrane separating two tissues i.e. defected nerve tissue and connective tissue. Inside the defected nerve tissue surrounded by the membrane should be present factors influencing the regeneration process such as: ECM protein, nervotrofic factors. On the other hand, the membrane should act as a barrier for fibroblast cells inflowing into the defected area. The work presents results of investigations on porous nanocomposite materials basing on bioresorbable aliphatic polyesters i.e. poly-(L/DL)-lactide and carbon nanotubes (CNT). All materials i.e. nanocomposite foils and porous materials were prepared using synthetic co-polymer of L/DL-lactide with L/DL ratio of 80/20 from Purac®. The polymer had the FDA attestation confirming its biocompability. As the nanofillers, two types of CNTs produced by Nanostructured and Amorphous Materials (Inc. Huston, USA) were used: MWCNTs (multi-wall carbon nanotubes; diameter 10-30 nm and length 1-2 μm) and SWCNTs (single-wall carbon nanotubes; diameter 0.7-2 nm and length 15-30 μm). Nanocomposite membrane materials (PLDLA/0.5% wt. MWCNTs and PLDLA/0.5% wt. SWCNTs) were prepared using combined methods: phase inversion and freeze-drying. Porous microstructure of the nanocomposites was investigated using SEM/EDS. It was found, that the presence of the CNT influenced shape, size (5-50 μm) and distribution of pores in the material (total porosity of PLDLA/ MWCNTs was about ~65% and PLDLA/S WCNTs was about ~35%). The nanoadditives increased mechanical properties of the membrane materials. For example addtition of the SWCNTs increased the membrane strength (RM) form 16 to 24 MPa. Physicochemical properties of the materials surface were investigated by means of wettability and surface energy measurements. It was shown that dispersion part of surface free energy decreased when SWCNTs were used as additives (from 4.5 mm/mJ PLDLA membrane to 0.7 mm/mJ PLDLA/SWCNTs), while in the case of the MWCNTs addition dispersion part of surface energy increased from 4.5 mm/mJ to 6.9 mm/mJ. Such PLDLA-based materials modified with CNTs (MWCNTs, SWCNTs) may be an attractive support for adhering cells. SWCNTs were more suitable nanoad- ditives for PLDLA-matrix membranes than MWCNTs, because such membranes were stronger, hydrophilic and much more bioactive.
Źródło:: Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 139-140
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Nanocomposite Polymer Scaffolds for Bone Tissue Regeneration
Autorzy:: Stodolak-Zych, E.
Frączek-Szczypta, A.
Wiecheć, A.
Błażewicz, M.
Powiązania:: https://bibliotekanauki.pl/articles/1490208.pdf
Data publikacji:: 2012-02
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 82.35.Np
Opis:: Nanocomposite polymer scaffolds for tissue engineering were prepared using leaching method. As a porogen there were used phosphate salts with different grain size (100-400 μm). Nanocomposite materials based on polylactide (PL/DLA) containing 2 wt% of ceramic bioactive nanoadditives $(SiO_2)$ were prepared. The nanoadditive was characterized by dynamic light scatering (DLS) (size) and the Brunauer-Emmett-Teller (specific surface area) methods. Morphology of the nanoparticles was observed using the transmission electron microscopy. The optimal concentration of the nanofiller in the polymer matrix was evaluated on the basis of in vitro tests of the nanocomposite foils contacted with osteoblast-like human cells of MG63 line. The morphology and porosity of the scaffold after leaching was evaluated using scanning electron microscopy and hydrostatic weighing. The bioactivity test made on the scaffolds demonstrated ability to nucleation of apatite structure on the material.
Źródło:: Acta Physica Polonica A; 2012, 121, 2; 518-521
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: The Study of Human Osteoblast-Like MG 63 Cells Proliferation on Resorbable Polymer-Based Nanocomposites Modified with Ceramic and Carbon Nanoparticles
Autorzy:: Wiecheć, A.
Stodolak-Zych, E.
Frączek-Szczypta, A.
Błażewicz, M.
Kwiatek, W.
Powiązania:: https://bibliotekanauki.pl/articles/1490257.pdf
Data publikacji:: 2012-02
Wydawca:: Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:: 82.35.Np
87.17.Ee
Opis:: Polymer-based nanocomposites containing biocompatible and bioactive nanocomponents seem to be excellent materials that could be used in many biomedical applications. The aim of this study was biological evaluation of resorbable polymer-based nanocomposites (PLA, PCL) and their modifications with ceramic nanoparticles (silica - $SiO_2$, montmorillonite - MMT) or carbon nanotubes. The nanocomposites were seeded with the human osteoblast-like MG 63 cells. After 1, 3 and 7 days of incubation, Trypan blue exclusion test was used to determine the viability and number of cells. The cell population density depending on incubation time and cell population doubling time was calculated. The cell proliferation abilities on the all applied nanocomposites and on control material (polystyrene cell culture plate) were also compared. The number of cells growing on the nanocomposite surfaces increased with the incubation time. The cell viability was not decreased for all applied materials during the entire study (97-100%). The ceramic nanoparticles and carbon nanotubes modified the bone cell growth and proliferation rate. Results of this study confirm that all types of the nanocomposites are appropriate to the growing and proliferation of human osteoblast-like cells.
Źródło:: Acta Physica Polonica A; 2012, 121, 2; 546-550
0587-4246
1898-794X
Pojawia się w:: Acta Physica Polonica A
Dostawca treści:: Biblioteka Nauki

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